Have you ever found yourself busily attending to a patient’s acute problem when all of a sudden a nagging voice inside your head reminds you that you haven’t yet asked the patient about that needed flu shot, Pap smear, tetanus shot or other preventive service? Although health plans and government agencies are often quick to remind us of our preventive failures, many physicians shy away from pre...

Infections with both Epstein-Barr virus (EBV) and malaria have been impl icated as causal factors in the pathogenesis of Burkitt 's lymphoma (BL). Proposed trials of preventive measures for both infections are receiving serious consideration as possible means of establishing a causal relationship with BL. In this paper we examine certain models for the interaction of EBV and malaria in the indu...

Infections with both Epstein-Barr virus (EBV) and malaria have been implicated as causal factors in the pathogenesis of Burkitt's lymphoma (BL). Proposed trials of preventive measures for both infections are receiving serious consideration as possible means of establishing a causal relationship with BL. In this paper we examine certain models for the interaction of EBV and malaria in the induct...

multi-national vaccine trials, I will refer primarily to the UNAIDS Guidance Document, Ethical Considerations in HIV Preventive Vaccine Research (hereafter, Guidance Document) [1]. This document, which was developed in the mid-1990s, states that its scope is limited to multinational trials of HIV preventive vaccines. However, I suggest that it is more generally relevant to multinational trials,...