The preparation of substituted aminooxazoles and aminoimidazoles from α-arylamides and α-aminoamides through triflic anhydride-mediated amide activation is reported. These reactions proceed via the intermediacy of nitrilium adducts and feature N-oxide-promoted umpolung of the α-position of amides as well as a mechanistically intriguing sequence that results in sulfonyl migration from nitrogen t...

The internal strain in cyclic amides are explained as a factor of resonance that are effected on the bond length C-N  and are a major factor of rates of hydrolysis. The cyclic amides in this study are optimized by Gaussian program and the bond length of C-N in the rings are studied by HF/6-31G*.  

The internal strain in cyclic amides are explained as a factor of resonance that are effected on the bond length C-N and are a major factor of rates of hydrolysis. The cyclic amides in this study are optimized by Gaussian program and the bond length of C-N in the rings are studied by HF/6-31G*.

Mesoporous MCM-41 silicas anchored with sulfonic acid (–SO3H) groups (denoted MSN-SA) via postsynthesis modification are very effective for the Beckman rearrangement. A simple and convenient procedure for conversion of a variety oximes to their corresponding amides and lactams has been developed. The reaction was carried out in the presence of MSN-SA as the catalyst. The best results for conver...

Streptonigrin has been shown to be a potent cytotoxic agent, with broad spectrum activity in a number of murine tumor models1\ Recently it was shown that streptonigrin is a nonintercalative antibiotic, which induces mammaliantopoisomerase II dependent DNAcleavage2). It is a strong inhibitor of the reverse transcriptase associated with avian myeloblastosis virus and humanimmunodeficiency virus3)...

Supercritical carbon dioxide can be employed as an environmentally friendly alternative to conventional organic solvents for the synthesis of a variety of carboxylic amides. The addition of amines to ketenes generated in situ via the retro-ene reaction of alkynyl ethers provides amides in good yield, in many cases with ethylene or isobutylene as the only byproducts of the reaction. Reactions wi...

Introduction One of the aims of our research programme is to determine the molecular architecture of the ion channel buried deep within certain subtypes of glutamic acid-gated receptor (GluR), i.e. ionotropic not metabotropic GluR. This will require an interdisciplinary approach, but selective pharmacological tools are now available with which to begin to classify GluR subtypes. Such tools incl...