Volume-sensitive K-Cl cotransport occurs in red blood cells of many species. In intact cells, activation of K-Cl cotransport by swelling requires dephosphorylation of some cell protein, but maximal activity requires the presence of intracellular ATP. We have examined the relation between K-Cl cotransport activity and ATP in ghosts prepared from human red blood cells. K-Cl cotransport activity i...

Weidong Min Abstract. This paper presents an algorithm based on shrunken polyhedron and mapping to mesh a convex polyhedron using mixed elements, with mostly hexahedra, but including some tetrahedra, pyramids, and wedges. It is part of a scheme for automatically meshing an arbitrary 3D geometry. The scheme rst decomposes a 3D geometry into a set of convex polyhedra. Then the boundary quadrilate...

Background: Pediatric gliomas (PGs) are highly aggressive and predominantly occur in young children. In pediatric gliomas, abnormal expression of Homeobox (HOX) family genes (HFGs) has been observed is associated with the development progression disease. Studies have found that overexpression or underexpression certain HOX linked to occurrence prognosis gliomas. This aberrant may contribute dys...

This study investigates acoustic characteristics of Aymara ejectives. Acoustic measurements of the Aymara ejectives were conducted in terms of the durations of the release burst, the vowel, and the intervening gap (VOT), the intensity and spectral centroid of the release burst, and H1-H2 of the initial part of the vowel. Results showed that ejectives vary with place of articulation in the durat...

Previously, we reported that hyposmotic swelling evoked transient vascular smooth muscle cell (SMC) contraction that was completely abolished by L-type Ca(2+) channel blockers. In contrast, sustained contraction revealed in hyper- and isoosmotically-shrunken SMCs was insensitive to L-type channel blockers and was diminished in Ca(2+)-free medium by only 30-50%. Several research groups reported ...

Shrunken Pore Syndrome was recently suggested for the pathophysiologic state in patients characterized by an estimation of their glomerular filtration rate (GFR) based upon cystatin  C, which is lower or equal to 60% of their estimated GFR based upon creatinine, i.e. when eGFR cystatin  C ≤ 60% of eGFR creatinine. Not only the cystatin C level, but also the levels of other low molecular mass pr...

The transcription factor, tonicity-responsive enhancer binding protein (TonEBP), is involved in the adaptive response against hypertonicity. TonEBP regulates the expression of genes that catalyze the accumulation of osmolytes, and its transcriptional activity is increased by hypertonicity. The goal of the present investigation was to investigate whether cell shrinkage or high intracellular ioni...