نتایج جستجو برای: pred
تعداد نتایج: 1230 فیلتر نتایج به سال:
The CHRNA3 rs1051730 polymorphism has been associated to chronic obstructive pulmonary disease (COPD), lung cancer and nicotine dependence in case-control studies with high smoking exposure; however, its influence on lung function and COPD severity in the general population is largely unknown. We genotyped 57,657 adult individuals from the Copenhagen General Population Study, of whom 34,592 wer...
OBJECTIVE To compare the efficacy of a single dose of oral dexamethasone (Dex) versus 5 days of twice-daily prednisolone (Pred) in the management of mild to moderate asthma exacerbations in children. STUDY DESIGN A prospective, randomized, double-blinded trial of children 2 to 16 years of age who presented to the emergency department (ED) with acute mild to moderate asthma exacerbations. Subj...
Objective: Short-term inflammation stimulates the sympathetic nervous system (SNS) and the hypothalamic – pituitary – adrenal (HPA) axis. The activity of the HPA axis is reduced in chronic inflammatory diseases, however, the behavior of the SNS is not similarly understood. This study was initiated to study in parallel the tone of both endogenous response system in patients with systemic lupus e...
BACKGROUND An impairment of CO diffusing capacity has been shown in diabetic patients without lung disease. We analyzed how diffusing capacity in patients with COPD is affected by the concurrent diagnosis of diabetes. METHODS Data from the initial visit of the German COPD cohort COSYCONET were used for analysis. 2575 patients with complete lung function data were included, among them 358 defi...
Glucocorticoids cause muscle atrophy and weakness, but the mechanisms for these effects are unclear. The purpose of this study was to test a hypothesis that prednisone (Pred) counteracts insulin's anabolic effects on muscle. A randomized, double-blind cross-over design was used to test the effects of 6 days either Pred (0.8 mg x kg(-1) x day(-1)) or placebo use in seven healthy young volunteers...
This prospective, randomized study investigates the effect of two immunosuppressive treatment regimens on quality of life after renal transplantation. At 3 months after transplantation, patients treated with cyclosporine (CsA) and prednisone (Pred) were allocated to either withdrawal of Pred (n = 60) or to conversion of CsA to azathioprine (Aza) (Aza-Pred, n = 60). Quality of life was evaluated...
Discovery Oncology, Pharma Research and Early Development (pRED), Roche Diagnostics GmbH, Penzberg, 8 Germany; Discovery Oncology, pRED, Roche Glycart AG, Schlieren, Switzerland; Department Of Nuclear 9 Medicine, Singapore General Hospital; National Cancer Center, Singapore; Roche Translational Medicine 10 Hub, Singapore; Biologics Research, pRED, Roche Diagnostics GmbH, Penzberg, Germany; Roch...
In order to distinguish the effects of lung disease from those of normal growth and development, lung function is expressed in comparison with reference data, with forced expiratory volume in 1 s (FEV1) commonly being presented as % predicted. FEV1 % pred has been identified as being of prognostic value in cystic fibrosis (CF), such that an FEV1 of ,30% pred or rapid decline to that level shoul...
Usually, in data processing, to find the parameters of the models that best fits the data, people use the Least Squares method. One of the advantages of this method is that for linear models, it leads to an easy-to-solve system of linear equations. A limitation of this method is that even a single outlier can ruin the corresponding estimates; thus, more robust methods are needed. In particular,...
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