BACKGROUND Follicular fluid meiosis-activating sterol (FF-MAS) protects young oocytes from precocious chromatid separation (predivision). Reduced expression of cohesion and checkpoint proteins and predivision has been hypothesized to occur in age-related aneuploidy in oocytes. METHODS To know whether FF-MAS also protects aged oocytes from predivision and from age-related non-disjunction, we a...

The Committee of Central Precocious Puberty Korean Pediatrics and Adolescents the Society Pediatric Endocrinology has newly developed evidence-based 2022 clinical practice guidelines for central precocious puberty in children adolescents. These provide grade recommendations, which includes both strength recommendations level evidence. In absence sufficient evidence, are based on expert opinion....

Precocious puberty refers to the appearance of physical and hormonal signs of pubertal development at an earlier age than is considered normal. In girls, the telltale signs of precocious puberty include any of the following symptoms before 7 or 8 years of age: breast development, pubic or underarm hair development, rapid height growth a growth "spurt", onset of menstruation, acne and "mature" b...

Precocious Puberty in a 2-year-old boy  A 2-year-old boy with precocious isosexual matura- (3) Lion is reported.  The pubertal values of serum LH, FSH and Testoste- (4) on and lack of any other pathologic finding were in favour of diagnosis of idiopathic sexual precocity.  The L.R.F. response test was of the adult pattern. The serum LH, FSH and Testosterone decreased following (5) treatment ...

We present a five year old boy with central precocious puberty and pineal gland cyst on neuroimaging. This association is uncommon and highlights the role of pineal gland in puberty.

PURPOSE The progressivity of central precocious puberty (CPP) seems to depend on the age at presentation. We evaluated the clinical courses of CPP girls according to their age at initiation of treatment. METHODS One hundred thirty five girls with CPP diagnosed between Jan. 2003 and Dec. 2009 and regularly followed for more than one year were included. They were treated with gonadotropin-relea...

OBJECTIVE Gonadotropin stimulation test is the gold standard to document precocious puberty. However, the test is costly, time-consuming and uncomfortable. The aim of this study was to simplify the intravenous gonadotropin-releasing hormone (GnRH) stimulation test in the diagnosis of precocious puberty and in the assessment of pubertal suppression. METHODS Data pertaining to 584 GnRH stimulat...

BACKGROUND Few studies have explored the trends in central precocious puberty (CPP) in Asian populations. This study assessed the prevalence and annual incidence of CPP among Korean children. METHODS Using data from the Korean Health Insurance Review Agency from 2004 to 2010, we reviewed the records of 21,351 children, including those registered with a diagnosis of CPP for the first time and ...

The aetiology of 197 girls and 16 boys presenting with sexual precocity was reviewed. Ninety one girls and four boys had central precocious puberty (M:F 23:1); a cause was identified in all the boys but in only six girls. All boys with precocious puberty need detailed investigation; in girls investigation should be based on clinical findings, particularly the consonance of puberty.

BACKGROUND There are no absolute criteria for identifying those girls with idiopathic central precocious puberty (CPP) who will benefit from gonadotropin-releasing hormone analog (GnRHa) treatment. Our objective was to predict at initial evaluation the differences between adult height (AH) and target height (TH) and (for untreated girls) the time between puberty onset and first menstruation. ...