In this issue of The Oncologist, we begin a series of articles that consider the often problematic challenge of understanding and applying genomic information to the practice of oncology. Bardia et al. [1] describe the genomic findings from a patient with estrogen receptor (ER)-positive breast cancer after progression on hormonal therapy. In this case, tumor profiling revealed an ESR1 mutation ...

Every human being is different based on genetics, lifestyle, and environmental factors. Novel medical technologies have become more precise owing to molecular information, including genomics, transcriptomics, proteomics, metabolomics, etc. The “omics” technologies have opened up new horizons for healthcare systems, enabling them to prevent and/or diagnose diseases more precisel...

We will introduce precision medicine and showcase the vast opportunities for NLP in this burgeoning field with great societal impact. We will review pressing NLP problems, state-of-the art methods, and important applications, as well as datasets, medical resources, and practical issues. The tutorial will provide an accessible overview of biomedicine, and does not presume knowledge in biology or...

Medicine is now undertaking a paramount revolution that will alter the nature of healthcare from reactive to proactive. It is imperative to integrate experimental and computational investigation in order to appreciate complex biological systems in the era of precision medicine. In light of this revolution, we necessitate to precision medicine means such as systems approaches (genomics, radiogen...

In the future, precision medicine will enable every clinician to tailor treatment and even prevention strategies to an individual's unique characteristics. In order to reach this goal, we need to collect and analyze many different types of data, from many different sources, including symptoms, genomics, and brain circuitry, as well as family dynamics, environmental exposures, and cultural backg...

In the recent decades, major biotechnological advances have been achieved following the sudden escalation of disease-related molecular information, with the potential for greatly advancing patient care. The human genome was depicted in year 2000, followed by the completion of the human genome project in 2003. Scientists have ignited a firestorm of breakthroughs in genomic information, by laying...