Since the prognosis of advanced biliary tract cancer (aBTC) still remains very poor, new therapeutic approaches, including immunotherapies, need to be developed. In the current study, we conducted an open-label randomized phase II study to test whether low dose cyclophosphamide (CPA) could improve antigen-specific immune responses and clinical efficacy of personalized peptide vaccination (PPV) ...

A stable, hydrogen-defect structure of post-perovskite (hy-ppv, Mg1 xSiH2xO3) has been determined by first-principles calculations of the vibrational and elastic properties up to 150 GPa. Among three potential hy-ppv structures analyzed, one was found to be stable at pressures relevant to the lower-mantle D 00 region. Hydrogen has a pronounced effect on the elastic properties of post-perovskite...

INTRODUCTION Prune dwarf ilarvirus (PDV) and its various strains cause many types of stone fruit diseases of considerable economic importance (Nemeth, 1986). The virus induces considerable damage in many hosts either by itself or in a mixed infection with other stone fruit viruses. PDV is transmitted naturally by infected pollen. PDV has worldwide distribution, especially where sweet and sour c...

In this work we studied the optical properties of poly[2-methoxy-5-(2’-ethylhexyloxy)-p-phenylene vinylene] (MEH-PPV) using polymeric blends with polystyrene (PS). The photoluminescence (PL) spectrum of MEHPPV present three characteristic peaks correlating to aggregate electronic transition at 608, 674 and 742 nm at 10K. An addition of PS in MEH-PPV films induces a red shift in the absorption s...

The present retrospective study aimed to investigate the frequency, risk factors, and anatomical and visual outcomes of retinal detachment (RD) after vitrectomy performed for dropped nucleus. Medical records of the patients who underwent pars plana vitrectomy (PPV) due to the development of dropped nucleus after cataract surgery by phacoemulsification between 2003 and 2014 in three different ce...

The prognosis of non-small cell lung cancer (NSCLC) patients who failed two or more treatment regimens remains very poor. We conducted a phase II study to explore the feasibility of personalized peptide vaccination (PPV), in which peptides are selected and administered based on the pre-existing host immunity before vaccination, as a third or more line treatment in advanced NSCLC patients who fa...

PURPOSE To evaluate the incidence and prevalence of cataract formation, progression, and extraction in patients that underwent vitreoretinal procedures and to evaluate factors that can potentially predispose patients to postoperative cataracts. MATERIALS AND METHODS The medical records of consecutive patients who underwent vitreoretinal surgery at the Yale Eye Center with at least 6 months of...

In order to fill in a decade-long information gap regarding the biological, serological and molecular data for plum tree viruses Bosnia Herzegovina, three-phase study combining symptom evaluation, assays with high-throughput sequencing (HTS) technology was conducted. The most frequently observed symptoms were discolorations form of ring patterns, bands irregular shapes, as well vein banding. Sh...

INTRODUCTION Pulse pressure variation (PPV) has been shown to predict fluid responsiveness in ventilated intensive care unit (ICU) patients. The present study was aimed at assessing the diagnostic accuracy of PPV for prediction of fluid responsiveness by using the grey zone approach in a large population. METHODS The study pooled data of 556 patients from nine French ICUs. Hemodynamic (PPV, c...

CMTC: Cutis marmorata telangiectatica congenita PPV: Phacomatosis pigmentovascularis INTRODUCTION The coexistence of cutis marmorata telangiectatica congenita (CMTC) with Mongolian spots has been reported as a distinct type of phacomatosis pigmentovascularis (PPV), namely PPV type V or phacomatosis cesiomarmorata. PPV type V is a rare congenital vascular anomaly, with only 7 previous cases ment...