HULC is a long noncoding RNA overexpressed in hepatocellular carcinoma (HCC), but its functional contributions in this setting have not been determined. In this study, we explored the hypothesis that HULC contributes to malignant development by supporting abnormal lipid metabolism in hepatoma cells. HULC modulated the deregulation of lipid metabolism in HCC by activating the acyl-CoA synthetase...

To determine whether selected genes and plasma markers involved in energy homeostasis are associated with sleep disruption or duration adults HIV/AIDS. A sample of 289 HIV/AIDS wore a wrist actigraph for 72 h to estimate total time (TST) wake after onset (WASO). Twenty-three single nucleotide polymorphisms (SNP) spanning 5 (adiponectin [ADIPOQ], ghrelin [GHRL], leptin [LEP], peroxisome prolifer...

Reddy, Janardan K. Nonalcoholic Steatosis and Steatohepatitis. III. Peroxisomal b-oxidation, PPARa, and steatohepatitis. Am J Physiol Gastrointest Liver Physiol 281: G1333–G1339, 2001.—Peroxisomes are involved in the b-oxidation chain shortening of long-chain and very-long-chain fatty acyl-CoAs, long-chain dicarboxylyl-CoAs, the CoA esters of eicosanoids, 2-methyl-branched fatty acyl-CoAs, and ...

The biological role of the peroxisome proliferator-activated receptors (PPARs) in various diseases, including inflammation and cancer, has been highlighted recently. Although PPARg ligands have been found to inhibit mammary carcinogenesis in rodents, the effects on colon tumorigenesis are controversial. In the present study, three different experiments were conducted to investigate the modifyin...

Disruption of lipid and carbohydrate homeostasis is an important factor in the development of prevalent metabolic diseases such as diabetes, obesity, and atherosclerosis. Therefore, small molecules that could reduce insulin dependence and regulate dyslipidemia could have a dramatic effect on public health. The grapefruit flavonoid naringenin has been shown to normalize lipids in diabetes and hy...

OBJECTIVE The aim of the present study was investigate the association between six genetic variants in the nuclear receptor genes PPARA, RXRA, NR1I2 and NR1I3 and the lipid-lowering efficacy and safety of statin therapy. SUBJECTS AND METHODS The study was carried out on 240 Brazilian hypercholesterolemic patients on simvastatin and atorvastatin therapy. The polymorphisms were analyzed by PCR-...

BACKGROUND AND AIMS Whether EPA and DHA exert similar anti-inflammatory effects through modulation of gene expression in immune cells remains unclear. The aim of the study was to compare the impact of EPA and DHA supplementation on inflammatory gene expression in subjects at risk for cardiometabolic diseases. METHODS In this randomized double-blind crossover trial, 154 men and women with abdo...

Objective. To study the polymorphisms of genes involved in angiogenesis and metabolic processes, to assess level lymphocytes patients with chronic endometritis practically healthy women reproductive period.
 Materials methods. 86 were examined; DNA regions eNOS 1799983 (Glu298Asp), PPARA (G2528C), ApoE rs429358 (Cys130Arg), MTHFR (C677T, A1298C) used as primers; blood (CD3+, CD4+, CD8+, CD...

The WNT/b-catenin signaling pathway has been identified as an important endogenous regulator of hepatic cytochromeP450 (P450) expression inmouse liver. In particular, it is involved in the regulation of P450 expression in response to exposure to xenobiotic agonists of the nuclear receptors constitutive androstane receptor (CAR), aryl hydrocarbon receptor (AhR), and Nrf2. To systematically eluci...