نتایج جستجو برای: pou1f1
تعداد نتایج: 147 فیلتر نتایج به سال:
Over the last 5 years, new actors involved in the pathogenesis of combined pituitary hormone deficiency in humans have been reported: they included a member of the immunoglobulin superfamily glycoprotein and ciliary G protein-coupled receptors, as well as new transcription factors and signalling molecules. New modes of inheritance for alterations of genes encoding transcription factors have als...
Abstract Pit-1 (POU1F1) is a POU-homeodomain transcription factor, and it one of the most important tissue-specific factors in pituitary development. Cyclin-dependent kinase 5 (CDK5) protein that can phosphorylate many key factors, but mechanism under which CDK5 phosphorylates unclear. To investigate whether regulate cell proliferation promote hormone secretion through phosphorylation Ser126-Pi...
We examined the role of WNT signaling in pituitary development by characterizing the pituitary phenotype of three WNT knockout mice and assessing the expression of WNT pathway components. Wnt5a mutants have expanded domains of Fgf10 and bone morphogenetic protein expression in the ventral diencephalon and a reduced domain of LHX3 expression in Rathke's pouch. Wnt4 mutants have mildly reduced ce...
The mechanisms by which transient gradients of signaling molecules lead to emergence of specific cell types remain a central question in mammalian organogenesis. Here, we demonstrate that the appearance of four ventral pituitary cell types is mediated via the reciprocal interactions of two transcription factors, Pit1 and GATA2, which are epistatic to the remainder of the cell type-specific tran...
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