BACKGROUND Keratoconus typically presents in the teenage years and is more advanced in younger patients when compared with adults. In the present study, we aimed to assess the safety and efficacy of accelerated transepithelial corneal collagen cross-linking (ATE-CXL) in children with progressive keratoconus. METHODS In this retrospective consecutive study, 18 eyes were enrolled from 17 pediat...

Results. Abnormalities in collagen organization were seen in both the anterior and posterior stroma of the keratoconus cornea (Figure 2), with the most drastic disruption occurring within the region of greatest corneal steepening (Figure 1). In the posterior stroma, the normal orthogonal predominant orientation of collagen was absent; in the anterior stroma, the usual isotropic arrangement of c...

purpose: to compare keratocyte density in stromal layers of the cornea in keratoconus, post-lasik keratectasia, lasik without keratectasia, and normal corneas by confocal scan. methods: thirty-one unscarred corneas from 22 patients with keratoconus, 24 clear corneas from 17 cases with post-lasik keratectasia, 12 corneas from 7 lasik cases without keratectasia, and 26 corneas from 13 normal subj...

PURPOSE The exact pathophysiological processes underlying keratoconus remain an enigma. In this study, laser scanning in vivo confocal microscopy (IVCM) was used to define further the microstructural abnormalities in the keratoconic cornea and to establish the relationship with disease severity. METHODS This was a prospective, cross-sectional study comparing 52 subjects with keratoconus and 5...

PURPOSE Mutations in the visual system homeobox 1 (VSX1) gene have been described at a low frequency in keratoconus and posterior polymorphous corneal dystrophy (PPCD). The putative role is controversial for several reasons, including a lack of mutations detected in other population cohorts. This study aims to determine whether VSX1 contributes to the genetic pathogenesis of keratoconus and PPC...

AIM To establish a new procedure for 3D geometric reconstruction of the human cornea to obtain a solid model that represents a personalized and in vivo morphology of both the anterior and posterior corneal surfaces. This model is later analyzed to obtain geometric variables enabling the characterization of the corneal geometry and establishing a new clinical diagnostic criterion in order to dis...

· AIM: To quantify corneal ultrastructure using laser scanning confocal microscopy (IVCM) in patients with keratoconus and control subjects. · METHODS: Unscarred corneas of 78 keratoconic subjects without a history of contact lens use and 36 age-matched control subjects were evaluated with slitlamp examination (SLE), corneal topography and laser scanning IVCM. One eye was randomly chosen for an...

keratoconus is a non-inflammatory, progressive thinning process of the cornea. it is a relatively common disorder of unknown etiology that can involve each layer of the cornea and often leads to high myopia and astigmatism. computer- assisted corneal topography devices are valuable diagnostic tools for the diagnosis of subclinical keratoconus and for tracking the progression of the disease. the...