An integrated model for magnetoencephalography (MEG) and functional Magnetic Resonance Imaging (fMRI) is proposed. In the proposed model, MEG and fMRI outputs are related to the corresponding aspects of neural activities in a voxel. Post synaptic potentials (PSPs) and action potentials (APs) are two main signals generated by neural activities. In the model, both of MEG and fMRI are related to t...

Changes in spontaneous activity within the cortex recognized by subthreshold fluctuations of the membrane potential of cortical neurons modified the response of cortical neurons to sensory stimuli. Sensory stimuli occurring in the hyperpolarized "down" state evoked a larger depolarization and were more effective in evoking action potentials than stimuli occurring in the depolarized "up" state. ...

Associative synaptic plasticity is synapse specific and requires coincident activity in pre-synaptic and post-synaptic neurons to activate NMDA receptors (NMDARs). The resultant Ca(2+) influx is the critical trigger for the induction of synaptic plasticity. Given its centrality for the induction of synaptic plasticity, a model for NMDAR activation incorporating the timing of pre-synaptic glutam...

On June 6, 2011, the Section of Epidemiology (SOE) of the Alaska Division of Public Health was notified of a case of paralytic shellfish poisoning (PSP) in southeast Alaska. In collaboration with local partners, SOE investigated and identified a total of eight confirmed and 13 probable PSP cases that occurred during May--June 2011. Warnings to avoid noncommercially harvested shellfish were broa...

Process improvements within software development occur at three different levels: the organizational level, the project/team level, and at the individual engineer -or personal -level. The Software Engineering Institute (SEI) of Carnegie Mellon University has developed process improvement models tailored to each of these levels. The Capability Maturity Model (CMM) deals with organization issues,...

The attitude towards one's own imperfection strongly varies between individuals. Here, we investigated variations in error-related activity depending on two sub-traits of perfectionism, Personal Standard Perfectionism (PSP) and Evaluative Concern Perfectionism (ECP) in a large scale functional magnetic resonance imaging study (N = 75) using a digit-flanker task. Participants with higher PSP sco...

Progressive supranuclear palsy (PSP) is a debilitating progressive neurodegenerative disorder for which there is no proven pharmacological treatment. Zolpidem immediate release formulation has been reported to show short-term improvements in motor function and voluntary saccadic eye movements, but the benefits were not sustained. A 61-year-old man with a 4-year history of PSP was observed over ...

INTRODUCTION Patients with rheumatoid arthritis (RA) who are treated with adalimumab (ADA) are offered a proprietary patient support program (PSP, AbbVie Care®). The main objective of this study was to examine the effectiveness of ADA on RA treatment course over time in the context of PSP utilization. METHODS PASSION was a 78-week post-marketing observational study of RA patients with an insu...

This study investigated the potential of pinon shell polysaccharide (PSP) to enhance immunity against H9N2 subtype avian influenza virus (H9N2 AIV) in chickens. The effect of PSP treatment and H9N2 virus infection after PSP pretreatment were investigated by [3-(4, 5-dimethylthiazol-2-yl)-2, 3-diphenyl tetrazolium bromide] assay and analysis of major histocompatibility complex and cytokine mRNA ...