Ketamine (KET) induced blockade of cortical spreading depression (CSD) declines with repeated KET applications in a way suggesting the development of tolerance. Possible mechanism of this process was studied in 31 rats anestheized with pentobarbital. CSD was elicited by injection of 1µl of 5% KCl into cortex at 15 min intervals and monitored by recording the accompanying slow potential waves....

Objective(s): The protozoan Toxoplasma gondii as an intracellular protozoan is widely prevalent in humans and animals. Infection generally occurs through consuming food contaminated with oocysts and tissue cysts from undercooked meat. The parasite is carried in sexual fluids like semen but there is little information about the effect of T. gondii on the male reproducti...

On the basis of see-saw mechanism, possible generation structure is investigated. Assuming that right-handed neutrinos are realistic particles below GUTs mass, it is shown that there is a choice of new scheme of generation, where the combination of leptons and quarks is different from the ordinary one. Our scheme predict a new proton decay mode. 1 typeset using PTPTEX.sty §

We describe a mechanism for cold fusion that is able to explain how two hydrogen ions may come close enough so as to fusion as well as many of the different and independent experimental observations made during years of experiments. We present the mechanism, its weak points, the way it explains the respective phenomena and suggest some experiments that may validate further the model described b...

Described is a possible mechanism of binocular fusion In visual system based on continlous estimation of resulting "cor-tical image" doubling degree during ver-genoe eye movements. The mechanism does not require any search of corresponding sites in pair retinal images. The result of computer simulation of this mechanism are given. A sequence of information processing stages in binocular vision ...

Excess alcohol consumption may affect the cardiovascular system in various ways. Adverse effects include hypertension (McMahon, 1987), arrhythmias (Ettinger et al, 1978), cardiomyopathy (Urbano-Marquez et al, 1989) and haemorrhagic stroke (Camargo, 1989). One beneficial effect of moderate alcohol consumption appears to be some protection against morbidity and mortality from coronary heart disea...

After in vitro incubation with radiolabeled amino acids, extracts of various chicken tissues were reacted with antiserum against apolipoprotein AI (apo-AI) of plasma high density lipoprotein. Radiolabeled apo-AI was found in liver and intestine as well as in the kidney and a variety of peripheral tissues including aorta, peripheral arteries, veins, and skeletal muscle. The immunoreactive apo-AI...

Citation: Heidemann SR and Bray D (2015) Tension-driven axon assembly: a possible mechanism. As the contents of this issue of " Frontiers " attest, the study of the mechanical aspects of neuronal development has come a long way since the 1970's and 80's when we became interested in the topic. The vast majority of cells in multicellular organisms are continually pushed and pulled, compressed, an...

Adenomyosis, an estrogen-dependent inflammatory disease, is defined as the presence of endometrial glands and stroma deep within the myometrium [1]. The main clinical features of adenomyosis are dysmenorrhea and menorrhagia, which are significantly associated with peritoneal endometriosis in infertile patients at reproductive age [2,3]. The only difference between adenomyosis and endometriosis ...

Allostery is involved in the dynamic regulation of biological functions in proteins. Advances in allostery research have recently drawn great interest and brought allostery closer to the clinic. The present commentary describes the mechanism by which allostery may involve in from a cell-wide view and its contribution to the discovery of new therapeutics to diseases.