INTRODUCTION Culture-negative sepsis is a common but relatively understudied condition. The aim of this study was to compare the characteristics and outcomes of culture-negative versus culture-positive severe sepsis. METHODS This was a prospective observational cohort study of 1001 patients who were admitted to the medical intensive care unit (ICU) of a university hospital from 2004 to 2009 w...

Background: Neonatal sepsis is a clinical syndrome of bacteremia characterized by systemic signs and symptoms infection in the first 28 days life. Although, Positive blood culture gold standard for diagnosis neonatal septicemia, definitive results take at least 48–72 h, resulting treatment delay. Hence certain rapid diagnostic tests such as C-reactive protein, micro erythrocyte sedimentation ra...