Introduction Portal hypertension (PHT) may be caused by a wide variety of conditions, each with a different natural history. It frequently presents with bleeding from oesophageal varices, which is the commonest cause of serious upper gastrointestinal haemorrhage in children. Precise diagnosis, a sound understanding of the therapeutic options, and a multidisciplinary approach are essential for s...

223 Chronic liver diseases or liver injuries commonly result in increased intrahepatic resistance and subsequently lead to portal hypertension. Portal hypertension is associated with 2 distinct pathophysiologic features: hyper-dynamic circulation and formation of portal-systemic collaterals. 1 Hyperdynamic circulation is characterized by increased splanchnic blood flow, cardiac output, decrease...

Portal hypertension is the main complication of cirrhosis and is responsible for its most common complications: variceal hemorrhage, ascites, and portosystemic encephalopathy. Portal hypertension is the result of increased intrahepatic resistance and increased portal venous inflow, which in turn is the result of splanchnic vasodilatation. Vasodilatation (splanchnic and systemic) and hyperdynami...

Portal vein thrombus has been detected in patients with liver cirrhosis, pancreatitis, ulcerative colitis, septicemia, myeloproliferative disorder, and neoplasm. The formation of portal tumor thrombus by hepatocellular carcinoma is well recognized, because of its high incidence, and subsequent development of portal hypertension such as rupture of varices, ascites and liver failure indicates the...

Portal hypertension is one of the most significant complications of both acute and chronic liver diseases. It generally develops as a result of an increase in vascular resistance at the prehepatic, intrahepatic, or postherpetic level. An increase in portal blood flow may also contribute. The dominant cause of portal hypertension relates to liver cirrhosis which increases resistance through the ...

The portal vein carries approximately 1 500ml/min of blood from the small and large bowel, spleen and stomach to the liver. Any obstruction or increased resistance to flow, or, rarely, pathological increases in portal blood flow, may lead to portal hypertension. The causes of portal hypertension are categorised as prehepatic, intrahepatic and posthepatic. Although the differential diagnosis is ...

Objective(s): An increase in nitric oxide (NO) production has been reported in cirrhotic cardiomyopathy and, portal hypertension. Since minocycline has been shown to inhibit NO overproduction, we aimed to examine its role in a rat model of CCl4-induced cirrhotic cardiovascular complications. Materials and Methods: Portal pressure and inotropic responsiveness of isolated papillary muscles to is...

BACKGROUND Portal hypertension is one of the death reasons for the liver cirrhosis patients. The oxidative stress is related to the occurrence and development of portal hypertension in cirrhosis. Malondialdehyde (MDA), one of the lipid peroxides, increases substantially in cirrhotic patients. AIMS To evaluate the relevance between the MDA level and portal hypertension in cirrhotic patients. ...