To explore the hypothesis that load-induced fluid flow in bone is a mechano-transduction mechanism in bone adaptation, unit cell micro-mechanical techniques are used to relate the microstructure of Haversian cortical bone to its effective poroelastic properties. Computational poroelastic models are then applied to compute in vitro Haversian fluid flows in a prismatic specimen of cortical bone d...

S U M M A R Y This paper describes a new algorithm based on the spectral method for the computation of Stoneley wave dispersion and attenuation propagating in cylindrical structures composed of fluid, elastic and poroelastic layers. The spectral method is a numerical method which requires discretization of the structure along the radial axis using Chebyshev points. To approximate the differenti...

The radially outward flow of fluid into a porous medium occurs in many practical problems, from transport across vascular walls to the pressurization of boreholes. As the driving pressure becomes non-negligible relative to the stiffness of the solid structure, the poromechanical coupling between the fluid and the solid has an increasingly strong impact on the flow. For very large pressures or v...

The general theory for small dynamic motion superimposed upon large static deformation, or acoustoelasticity, is developed for isotropic fluid-filled poroelastic solids. Formulas are obtained for the change in acoustic wave speeds for arbitrary loading, both on the frame and the pore fluid. Specific experiments are proposed to find the complete set of third-order elastic moduli for an isotropic...

The immersed boundary method is a widely used mixed Eulerian/Lagrangian framework for simulating the motion of elastic structures immersed in viscous fluids. In the traditional immersed boundary method, the fluid and structure move with the same velocity field. In this work, a model based on the immersed boundary method is presented for simulating poroelastic media in which the fluid permeates ...

The cytoplasm is the largest part of the cell by volume and hence its rheology sets the rate at which cellular shape changes can occur. Recent experimental evidence suggests that cytoplasmic rheology can be described by a poroelastic model, in which the cytoplasm is treated as a biphasic material consisting of a porous elastic solid meshwork (cytoskeleton, organelles, macromolecules) bathed in ...

Despite the ubiquity of fluid flows interacting with porous and elastic materials, we lack a validated non-empirical macroscale method for characterizing the flow over and through a poroelastic medium. We propose a computational tool to describe such configurations by deriving and validating a continuum model for the poroelastic bed and its interface with the above free fluid. We show that, usi...

A novel approach is presented for the identification of constitutive parameters of linear poroelastic materials from indentation tests. Load-controlled spherical indentation with a ramp-hold creep profile is considered. The identification approach is based on the normalization of the time-displacement indentation response, in analogy to the well-known one-dimensional consolidation problem. The ...

This work determines the spatial and temporal distribution of cerebrospinal fluid (CSF) pressure and brain displacement during an infusion test in a spherically symmetric model of the brain. The response of CSF pressure and parenchymal displacement to blood pressure pulsations is determined in the solution. We use a spherically symmetric, three-component poroelastic model of the brain, differen...