نتایج جستجو برای: poor water solubility

تعداد نتایج: 788110  

2018

During the last two decades, many modern technologies have been established in the pharmaceutical research and development area. The automation of the drug discovery process by technologies such as high-throughput screening, combinatorial chemistry, and computer-aided drug design is leading to a vast number of drug candidates possessing a very good efficacy [1]. Unfortunately, many of these dru...

2014
Rashmi Sharma Saroj Jain Ravindra Tiwari

One of the biggest challenges faced by pharmaceutical scientists is poor solubility and bioavailability of new chemical entities (NCEs). According to BCS classification; approximately 25% of all compounds are classified as highly soluble and permeable. Nearly 40% of the new chemical entities currently being discovered are lipophilic so poorly water soluble drugs. BCS Class II and Class IV have ...

2018

During the last two decades, many modern technologies have been established in the pharmaceutical research and development area. The automation of the drug discovery process by technologies such as high-throughput screening, combinatorial chemistry, and computer-aided drug design is leading to a vast number of drug candidates possessing a very good efficacy [1]. Unfortunately, many of these dru...

Journal: :Journal of the science of food and agriculture 2011
Kamal Mjoun Kurt A Rosentrater

BACKGROUND The tremendous supply and low cost of distillers dried grains with solubles (DDGS) make it an attractive feedstuff for aquaculture diets. Also, several studies have shown that DDGS can be successfully fed to various finfish. The objective of this study was to evaluate the effects of inclusion rate of DDGS (0, 250, 500 g kg(-1) ), feed moisture content (350, 450 g kg(-1) ) and die ope...

Journal: :Molecules 2011
Maria Arlete Silva Pires Robson Augusto Souza Dos Santos Rubén Dario Sinisterra

Hydrochlorothiazide is a common diuretic antihypertensive drug of the thiazide family. Its poor aqueous solubility is one of the reasons for its limited bioavailability after oral administration. This work aimed at the development of a hydrochlorothiazide:β-cyclodextrin (HTZ:β-CD) pharmaceutical composition in order to improve water solubility and bioavailability of the drug. The HTZ:β-CD compl...

Journal: :iranian endodontic journal 0
mohammad ali saghiri islamic azad university of medical sciences jack ricci , new york university morteza daliri joupari 3. national institute for genetic engineering and biotechnology mohammad aeinehchi islamic azad university of medical sciences kamran ahmadi 5. material and energy research center (merc), karaj, iran niloofar bahramian islamic azad university of medical sciences

introduction : solubility of root filling materials is heavily influenced by the environment they are in contact with. this study compared the solubility of proroot mta in deionized water and synthetic tissue fluid. materials & methods: forty specimens of prepared mta were immersed in deionized water and synthetic tissue fluid (20 samples each). the solubility was assessed after 7 and 28 days. ...

2017
Nagasamy Venkatesh Dhandapani

Abstract—Cefixime, a BCS class II drug, is insoluble in water but freely soluble in acetone and in alcohol. The aqueous solubility of cefixime in water is poor and exhibits exceptionally slow and intrinsic dissolution rate. In the present study, cefixime and βCyclodextrin (β-CD) solid dispersions were prepared with a view to study the effect and influence of β-CD on the solubility and dissoluti...

2011
Tarun Garg

Gliclazide is a second-generation hypoglycaemic sulfonylurea that is useful in the treatment of Type 2 diabetes mellitus. It shows low aqueous solubility and dissolution rate and often shows low and irregular bioavailability after oral administration. This paper describes an approach to improve the Solubility of gliclazide by using solid dispersions (SDs) in polyethylene glycol 4000 (PEG 4000)....

2010
A. Sharma C.P. Jain

Solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. The poor solubility of carvedilol leads to poor dissolution and hence variation in bioavailability. The purpose of the present investigation was to increase the solubility and dissolution rate of carve...

2014
D. Hasa

Regardless of the administration route, the key factor for the success and reliability of any formulation is drug bioavailability, defined as the rate and extent at which the active drug is absorbed from a pharmaceutical form and becomes available at the site of drug action.1 Although metabolism and physiological factors highly affect drug absorption by living tissues, bioavailability is strong...

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