نتایج جستجو برای: pon1 activity

تعداد نتایج: 1134962  

Journal: :The Journal of clinical endocrinology and metabolism 2003
Mariano Sentí Marta Tomás Montserrat Fitó Tanja Weinbrenner María-Isabel Covas Joan Sala Rafel Masiá Jaume Marrugat

Paraoxonase (PON1) is an antioxidant enzyme closely associated with high-density lipoproteins. Low PON1 has been shown in oxidative stress-associated processes such as dyslipidemia, diabetes mellitus, advancing age, and smoking. Indeed, oxidative stress is related to the degree of insulin resistance, a key component of the metabolic syndrome. Therefore, the possible relationship between PON1 ac...

2014
Luciana Morganti Ferreira Maselli Joel da Cunha Eliana Battaggia Gutierrez Raul Cavalcante Maranhão Celso Spada Sérgio Paulo Bydlowski

BACKGROUND Paraoxonase-1 (PON1) activity is suggested to be altered in individuals infected with human immunodeficiency virus type-1 (HIV-1). We investigated PON1 activity in individuals receiving different regimens of highly active antiretroviral therapy (HAART). METHODS PON1 activity was evaluated in 91 HIV-1 seronegative and 624 HIV-1 infected individuals (115 were not undergoing therapy (...

Journal: :Biochemical pharmacology 2011
Manojkumar Valiyaveettil Yonas Alamneh Peter Rezk Lionel Biggemann Michael W Perkins Alfred M Sciuto Bhupendra P Doctor Madhusoodana P Nambiar

Human paraoxonase 1 (PON1) has been portrayed as a catalytic bioscavenger which can hydrolyze large amounts of chemical warfare nerve agents (CWNAs) and organophosphate (OP) pesticides compared to the stoichiometric bioscavengers such as butyrylcholinesterase. We evaluated the protective efficacy of purified human and rabbit serum PON1 against nerve agents sarin and soman in guinea pigs. Cataly...

Journal: : 2021

Abstract Introduction Paraoxonase 1 is an enzyme associated with high-density lipoprotein fraction and considered to present antioxidant activity. Objectives The aim of the study was assess arylesterase activity paraoxonase (PON1) in serum patients hypertension, due effect therapy before treatment. Patients Methods. conducted 76 primary hypertension 28 volunteers for control group. Hypertensive...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2001
B Mackness G K Davies W Turkie E Lee D H Roberts E Hill C Roberts P N Durrington M I Mackness

Human serum paraoxonase (PON1) hydrolyzes oxidized lipids in low density lipoprotein (LDL) and could therefore retard the development of atherosclerosis. In keeping with this hypothesis, several case-control studies have shown a relationship between the presence of coronary heart disease (CHD) and polymorphisms at amino acid positions 55 and 192 of PON1, which we associated with a decreased cap...

Journal: :Environmental and molecular mutagenesis 2011
Karen Huen Lisa Barcellos Kenneth Beckman Sherri Rose Brenda Eskenazi Nina Holland

Paraoxonase 1 (PON1) prevents oxidation of low-density lipoproteins and inactivates toxic oxon derivatives of organophosphate pesticides (OPs). More than 250 SNPs have been previously identified in the PON1 gene, yet studies of PON1 genetic variation focus primarily on a few promoter SNPs (-108, -162) and coding SNPs (192, 55). We sequenced the PON1 gene in 30 subjects from a Mexican-American b...

Journal: :Journal of the American College of Cardiology 2006
Marit Granér Richard W James Juhani Kahri Markku S Nieminen Mikko Syvänne Marja-Riitta Taskinen

OBJECTIVES The goal of this study was to examine the association between paraoxonase-1 (PON1) activity and concentration and the severity and extent of coronary artery disease (CAD). BACKGROUND Paraoxonase-1, a high-density lipoprotein-associated enzyme, is proposed to have an antiatherogenic effect by protecting low-density lipoproteins against oxidation. METHODS We studied PON1 activity a...

Journal: :Physiological research 2007
K Sumegová Z Nagyová I Waczulíková I Zitnanová Z Duracková

Paraoxonase 1 (PON1) seems to have a relevant role in detoxifying processes and in atherosclerosis. The aim of this study was to determine PON1 activity, the total antioxidant capacity, as well as entire lipid profile in children for screening of possible risk of atherosclerosis development. Serum PON1 arylesterase/paraoxonase activities were determined spectrophotometrically. The total antioxi...

Journal: :Journal of lipid research 2004
Philip W Connelly Graham F Maguire Dragomir I Draganov

Paraoxonase-1 (PON1) is known to be associated with high density lipoproteins. We optimized buffer conditions to obtain quantitative recovery of PON1 (arylesterase) activity and analyzed the distribution of PON1 in mice using a combination of size-exclusion chromatography and ultracentrifugation. Size-exclusion chromatography of mouse serum separated the esterase activity into two peaks, one ov...

2009
Jonathan N. Hofmann Matthew C. Keifer Clement E. Furlong Anneclaire J. De Roos Federico M. Farin Richard A. Fenske Gerald van Belle Harvey Checkoway

BACKGROUND Animal studies have demonstrated that low paraoxonase-1 (PON1) status (i.e., low catalytic efficiency and/or low plasma PON1 activity) is associated with neurotoxic effects after exposure to several organophosphate (OP) insecticides. However, few human studies have investigated associations between PON1 status and intermediate end points, such as serum cholinesterase [butyrylcholines...

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