Nano-sized FePt capsules with two types of ultrathin shell were fabricated using a template method for use in a nano-scale drug delivery system. One capsule was composed of an inorganic-organic hybrid shell of a water-soluble polymer and FePt nanoparticles, and the other capsule was composed of a network of fused FePt nanoparticles. We demonstrated that FePt nanoparticles selectively accumulate...

Previous work has shown that laulimalide, a sponge-derived natural product, resembles paclitaxel in enhancing tubulin assembly and in its effects on cellular microtubules. The two compounds, however, seem to have distinct binding sites on tubulin polymer. Nearly equimolar amounts of tubulin, laulimalide, and paclitaxel are recovered from microtubules formed with both drugs. In the present study...

• Oral drug delivery systems were prepared by single step co-axial electrohydrodynamic atomization with high processing yield. • Polymer carrier systems (PCS) suitable for the process and drugs were developed first. • Model drugs of different aqueous solubility were successfully incorporated in the PCS with 50-70% encapsulation efficiency. • This technique is a versatile platform for combined d...

In article number 2200199, Chao Zhao and co-workers report emulsion-induced polymersomes. Through a simple emulsification process, the polymer forms polymersomes within seconds, formed effectively encapsulate water-soluble drugs in them.

Synthetic polymers have transformed society in many areas of science and technology, including recent breakthroughs in medicine. Synthetic polymers now offer unique and versatile platforms for drug delivery, as they can be "bio-tailored" for applications as implants, medical devices, and injectable polymer-drug conjugates. However, while several currently used therapeutic proteins and small mol...

Fluorescent turn-on probes combined with polymers have a broad range of applications, e.g. for intracellular sensing of ions, small molecules, or DNA. In the field of polymer therapeutics, these probes can be applied to extend the in vitro characterization of novel conjugates beyond cytotoxicity and cellular uptake studies. This is particularly true in cases in which polymer conjugates contain ...

This review article describes the current status and recent advances of polymeric drugs with regard to their application in drug delivery system. Essentially polymer-drug conjugation aims to achieve improved drug targeting, decrease drug toxicity and overcome mechanisms of drug resistance. First generation conjugates used linear monomethoxy PEGs and other linear polymers. Modern polymeric chemi...

Self-assembly of amphiphilic polymer opens a new avenue in the biomedical field; particularly, amphiphilic polymer vesicles have generally shown promising potential in drug delivery applications. The advantage of nanoparticle for drug delivery is because of the direct injection of these kind molecules to the body which will circulate in the body without any coagulation or blocking. The amphiphi...

Chitosan is a versatile natural polymer. This article reviewed different aspects of Chitosan that’s including preparation and characterization of Chitosan with their applicability in pharmaceutical formulations. Also, the article included different derivatives of Chitosan and their use in different drug delivery system. This review emphasized that research on Chitosan based systems containing v...