We examine a Bayesian Markov-chain Monte Carlo framework for simultaneous segregation and linkage analysis in the simulated single-nucleotide polymorphism data provided for Genetic Analysis Workshop 16. We conducted linkage only, linkage and association, and association only tests under this framework. We also compared these results with variance-component linkage analysis and regression analys...

Fat mass and obesity associated gene ( FTO) is the most relevant polygene for obesity to date. It has been identified by genome wide association studies concerning body weight regulation. However, its functional relevance for the pathogenesis of obesity remains elusive. Studies in rodents provide data pointing to a central role of FTO through regulation of food intake. In addition, peripheral e...

In this study, a mixed model method using trait phenotype and marker information was developed for genetic evaluation of animals in a crossbred population originated from several founder genetic groups. The situation in which a cluster of QTLs is located in a particular chromosome region and is marked by two flanking markers is considered. With this method, the conditional expectation of the id...

An increasingly popular research method for identifying etiologic heterogeneity in psychiatric illness has been to compare the frequency of a risk factor in affected individuals with no affected relatives (sporadic cases) and in affected individuals with one or more affected relatives (familial cases). This paper presents a power analysis of this familial vs sporadic method, assuming a multifac...

Benzene is an established cause of human leukemia that is thought to act by producing chromosomal aberrations and altered in cell differentiation. In several recent studies increased levels of chromosomal aberrations in peripheral blood lymphocytes were correlated with a heightened risk of cancer, especially hematological malignancies. Thus, chromosomal aberrations may be a predictor of future ...

Recurrent spontaneous abortions (RSAs) occur in approximately 15 to 20% of all clinically recognizable pregnancies. Structural chromosome abnormalities result in increased risk of pregnancy loss. Parental chromosomal abnormalities are an important genetic cause of RSAs. Some cytogenetic investigations have been performed in various countries and regions to determine the pattern of chromosomal a...