The formation of polyene-polyyne-based nanocomposites by dehydrohalogenation the drop-cast-deposited polyvinylidene fluoride, assessment and ion-induced tailoring their gas sensing properties are reported. investigated structure was analyzed scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy, transmission Fourier-transform infrared revealing thickness-dependent incomplete ...

In PVC compounds, hydrogen chloride plays a fundamental role in ·H and ·OH radical trapping, lowering the flame energy during combustion. Furthermore, it yields actual Lewis acids promoting cross-linking of polyene sequences from degradation bringing char layer, protecting items flames. Therefore, is inherently flame-retarded. However, plasticized requires retardants smoke suppressants to enhan...

The chlorinated polyene aurantoic acid (1) and the 4-methylene sterol dehydroconicasterol (2) were isolated from the Indonesian sponge Theonella swinhoei, and their structures were elucidated by interpretation of spectroscopic data. Aurantoic acid is a unique member in the class of naturally occurring conjugated polyene derivatives, while dehydroconicasterol is the likely biogenetic precursor o...

The study and optimization of small molecule function is often impeded by the time-intensive and specialist-dependent process that is typically used to make such compounds. In contrast, general and automated platforms have been developed for making peptides, oligonucleotides, and increasingly oligosaccharides, where synthesis is simplified to iterative applications of the same reactions. Inspir...

Ring-whizzing was investigated by hybrid DFT methods in a number of polyene-Pt(diphosphinylethane) complexes. The polyenes included cyclopropenium(+), cyclobutadiene, cyclopentadienyl(+), hexafluorobenzene, cycloheptatrienyl(+), cyclooctatetraene, octafluorooctatetraene, 6-radialene, pentalene, phenalenium(+), naphthalene and octafluoronaphthalene. The HOMO of a d(10) ML2 group (with b2 symmetr...

A large number of Streptomyces bacteria with antifungal activity isolated from samples collected in the Trondheim fjord (Norway) were found to produce polyene compounds. Investigation of polyene-containing extracts revealed that most of the isolates produced the same compound, which had an atomic mass and UV spectrum corresponding to those of candicidin D. The morphological diversity of these i...

N'-glycyl derivative (4) of antibiotic 67-121-C was prepared from the N'-iodoacetate (2) by treatment with aqueous ammonium hydroxide (Scheme 1). This compound was found to be slightly more potent than the parent antibiotic. This was particularly significant as simple N-acyl derivatives (e.g. N'-acetyl) of antibiotic 67-121-C and of other polyene antibiotics have all proved to be much less pote...

Sir: The polyene macrolides are known as potent antifungal agents. However their use in therapy is limited by considerable toxicity and very poor water solubility. Many efforts had been taken to obvert these undesirable properties1-5). We report now a new group of derivatives of polyene macrolides exhibiting improved solubility in water and organic solvents and retaining the biological activity...

Linear oligoenes of 1,6-heptadiynes (derived from dialkyl dipropargylmalonates) with a single basic structure and up to 23 conjugated double bonds were synthesized through Wittig-like reactions between bimetallic Mo-alkylidene compounds and aldehyde-capped oligoenes. The relatively rigid and isomerically pure oligoenes have structures with alternating cis,trans conjugated double bonds in which ...

Recent success in the treatment of congenital blindness demonstrates the potential of ocular gene therapy as a therapeutic approach. The eye is a good target due to its small size, minimal diffusion of therapeutic agent to the systemic circulation, and low immune and inflammatory responses. Currently, most approaches are based on viral vectors, but efforts continue towards the synthesis and eva...