Leukocytes isolated from patients with polycythemia vera (PCV), a panmyelopathy, have increased metabolic activity during the resting and phagocytizing states. Phagocytes from patients with PCV were studied by counting particle ingestion, measuring hexose monophosphate shunt (HMP) activity by the conversion of glucose1-’4C tr, ‘4CO2, and determining 02 consumption and nitroblue tetrazolium (NBT...

BACKGROUND AND OBJECTIVE It has been suggested that the determination of serum erythropoietin (sEpo) may be useful in distinguishing between polycythemia vera (PV), relative polycythemia and secondary polycythemia (SP), but no conclusive evidence has yet been provided for this. In the present work, we evaluated the role of sEpo in the differential diagnosis of polycythemia vera and its usefulne...

KEY WORDS: Imatinib mesylate Polycythemia Vera Myeloproliferative disorder Myeloproliferative neoplasm Tyrosine kinase inhibitor Myelosuppressive therapy

With an increasing incidence of obesity, sleep apnea and other chronic pulmonary diseases, the prevalence of secondary polycythemia is expected to rise in adults. Phlebotomy is commonly utilized in the management of secondary polycythemia. Although supported by a number of studies demonstrating a transient improvement in cardiovascular and cerebrovascular physiology, the benefit of phlebotomy i...

1. Pearson TC, Messinezy M, Westwood N, Green AR, Bench AJ, Huntly BJ, et al. Polycythemia vera updated: diagnosis, pathobiology, and treatment. Hematology (Am Soc Hematol Educ Program) 2000:51–68. 2. Tefferi A. Polycythemia vera: a comprehensive review and clinical recommendations. Mayo Clin Proc 2003;78:174–94. 3. Birgegard G, Wide L. Serum erythropoietin in the diagnosis of polycythaemia and...

Polycythemia vera is a myeloproliferative disorder characterized by thrombotic complications both in the arterial and venous systems. We report the case of a 55-year-old patient affected by polycythemia vera, presenting with acute superior vena cava syndrome due to thrombosis of the upper part of the superior vena cava. Diagnosis was done clinically and by computed tomography scan and showed an...

We describe a 38 year-old woman with polycythemia vera who presented with fulminant hepatic failure due to acute Budd-Chiari syndrome. She had a history of abdominal pain and distention for 4 days. Laboratory and clinical findings showed fulminant hepatic failure due to acute Budd-Chiari syndrome. Diagnosis was confirmed with abdominal ultrasonography and doppler ultrasonography showing ascites...

Myeloproliferative neoplasia (MPN)-associated pulmonary hypertension (PH) is included in group five of the most recent clinical classification of PH.1 The MPNs are a heterogeneous group of disorders that includes disorders with primary expression of a myeloid phenotype and disorders characterized by expression of the Janus Kinase 2 (JAK2) mutation, p.V617F. The latter includes essential thrombo...

A patient with polycythemia vera who was treated with heparin for superficial septic thrombophlebitis developed heparin-induced thrombocytopenia and cerebral venous thrombosis with superior sagittal sinus occlusion 11 days after the institution of heparin therapy. We suggest that the severe thrombotic response to the heparin-induced platelet disorder in this patient occurred because the polycyt...