An intact adult male 14.3-yr-old red panda (Ailurus fulgens) presented for health examination with a history of slowly progressing loss of body condition. Abdominal radiographs revealed a truncated abdomen with poor serosal abdominal detail and multiple areas of spondylosis with some collapsed intervertebral disc spaces. On computed tomography, multiple ovoid hypoattenuating lesions were seen i...

BACKGROUND Nephronophthisis (NPHP), which affects multiple organs, is a hereditary cystic kidney disease (CKD), characterized by interstitial fibrosis and numerous fluid-filled cysts in the kidneys. It is caused by mutations in NPHP genes, which encode for ciliary proteins known as nephrocystins. The disorder affects many people across the world and leads to end-stage renal disease. The aim of ...

Autosomal dominant polycystic kidney disease (ADPKD) is a form of (PKD) in which cysts develop within the kidneys, causing kidneys to enlarge and lose function over time. ADPKD caused by mutations two major genes: PKD1 PKD2. By whole exome sequencing (WES), we identified heterozygous missense variant (NM_001009944: c.10529C>T, p.T3510M) proband from 2-generation Vietnamese family, presented ...

A fifty four years old male was followed in nephrology clinic since 1999 for hepatorenal polycystic disease. The patient was referred for abdominal distension with postprandial fullness. Family history of hepatorenal polycystic disease in the father, grandmother and a paternal aunt. On physical examination there was a globular abdomen, with multiple irregular masses, which imprint on the abdomi...

The polycystic kidney diseases (PKDs) are a group of disorders characterized by the growth of epithelial cysts from the nephrons and collecting ducts of kidney tubules. The diseases can be inherited or can be provoked by environmental factors. To investigate the molecular basis of the abnormal cell growth associated with PKD, c-myc protooncogene expression was studied in a mouse model for autos...

A 38-year-old man with known autosomal dominant polycystic kidney disease (ADPKD) was electively admitted to our institution for open bilateral nephrectomies. A routine computed tomography scan had demonstrated a cyst at the upper pole of the left kidney with changes suspicious of malignancy and para-aortic adenopathy. His serum creatinine level was 510 mmol/L and the estimated glomerular filtr...

BACKGROUND The mTOR pathway, which consists of mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), is activated in polycystic kidney disease (PKD) kidneys. Sirolimus and everolimus indirectly bind and inhibit mTORC1. A novel group of drugs, the mTOR kinase inhibitors, directly bind to mTOR kinase, thus inhibiting both mTORC1 and 2. The aim of the study was to determine the therapeutic effect o...