BACKGROUND AND OBJECTIVES Our study developed a fully automated method for segmentation and volumetric measurements of kidneys from magnetic resonance images in patients with autosomal dominant polycystic kidney disease and assessed the performance of the automated method with the reference manual segmentation method. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Study patients were selected ...

1. Sesso R, Anção MS, Madeira SA. Aspectos epidemiológico do tratamento dialı́tico na grande São Paulo. Revista da Associação Médica do Brasil 1994; 40: 10–14 2. Gabow P. Autosomal dominant polycystic kidney disease. N Engl J Med 1993; 329: 332–342 3. Dalgaard OZ, Søren N. Autosomal dominant polycystic kidney disease in the 1980s. Clin Genet 1989; 36: 320–325 4. Higashira E, Nutahara K, Kojima M...

The term polycystic kidney disease (PKD) has inappropriately been used to describe any kidney riddled with cysts(l). Polycystic kidney disease is a rare disorder and was seen in 16 patients whereas renal cysts occurred in 136 of 6521 consecutive autopsies in infants and children(2). The matter has been further complicated with the recognition of juvenile presentation of autosomal recessive(3) a...

BACKGROUND We set out to determine the prevalence of incidental intracranial aneurysms in first-degree relatives aged 30 years or more of people with intracranial aneurysms, and to see if polycystic kidney disease contributes to the aggregation of familial intracranial aneurysms. METHODS 91 families with two or more affected members had previously been identified from a 14 year series of 1150...

Autosomal dominant polycystic kidney disease is a genetic disorder which results in the development of multiple cysts in the kidneys and other parenchymal organs. The two genes in which mutations are known to cause autosomal dominant polycystic kidney disease are PKD1 and PKD2. Approximately 50% of individuals with autosomal dominant polycystic kidney disease will develop end-stage renal diseas...

Information of 82 children in Finland, treated during the years 1974 to 1983 for polycystic kidney disease, was collected retrospectively. The occurrence was of the order of 1:8000 births. Fifty-one of the children had early lethal disease and 31 survived for over 28 days. These children came from 69 families. They were divided by family studies into three groups: autosomal dominant polycystic ...

Polycystic kidney disease is an inherited multisystem disorder. It causes progressive loss of kidney function, flank pain, urinary tract infection, arterial hypertension and vascular abnormalities. Until the present time the treatment of polycystic kidney disease has been symptomatic. New approaches based on cell culture of cyst wall epithelia and on the discovery of polycystins 1 and 2 have le...

Genetic mutations of discrete loci are the cause of a diverse array of polycystic kidney disease syndromes which present in distinct, as well as overlapping, phenotypic and hereditary patterns. Since molecular diagnostics are not currently a feasible clinical tool for the diagnosis of most cystic kidney diseases, physicians must rely upon their clinical acumen and knowledge base in order to ide...