A phase III clinical trial to test the effectiveness of the HIV microbicide Ushercell was recently stopped because interim analysis indicated that the rate of infection with HIV in women using the microbicide was higher than the rate of infection in those using the placebo. Ushercell, which was being developed by the nonprofit reproductive health organization CONRAD, is a cellulose sulfate comp...

Recent studies on the inhibition of pancreatic ribonuclease with polyanions (1-12) indicated that competing electrostatic interaction forces predominantly determine whether the cationic enzyme interacts with the polyanionic inhibitor or whether it interacts with its high or low molecular weight anionic substrate (ribonucleic acid or nucleotide cyclic 2’) 3’-phosphate). Similar polyanionic inhib...

losartan potassium is a well known orally active non-peptide angiotensin ii receptor antagonist. losartan potassium and its principle active metabolites block the vasoconstrictor and aldosterone secreting effect of angiotensin ii by selectively blocking the binding of angiotensin ii to at1 receptors. the drug is reported to promote the decrease in ventricular hypertrophy, salt and water excreti...