نتایج جستجو برای: polyamidoamine dendrimer

تعداد نتایج: 2442  

2009
Hidetoshi Arima Keiichi Motoyama

We have evaluated the potential use of various polyamidoamine (PAMAM) dendrimer [dendrimer, generation (G) 2-4] conjugates with cyclodextrins (CyDs) as novel DNA and RNA carriers. Among the various dendrimer conjugates with CyDs, the dendrimer (G3) conjugate with α-CyD having an average degree of substitution (DS) of 2.4 [α-CDE (G3, DS2)] displayed remarkable properties as DNA, shRNA and siRNA ...

2008
Hannah S. Halliday Bert D. Chandler John D. Gilbertson

Introduction The desire to controllably tune catalyst properties has generated increased interest in the controlled preparation of supported nanoparticle catalysts. Particle size, composition, and morphology may have substantial influences on catalytic activity and, more importantly, selectivity. However, few preparative routes exist to prepare supported catalysts of welldefined morphologies. S...

2016
Zhanfei Chen Fen Lian Xiaoqian Wang Yanling Chen Nanhong Tang

The polyamidoamine (PAMAM) dendrimer, a type of macromolecule material, has been used in spheroidal cell culture and drug delivery in recent years. However, PAMAM is not involved in the study of hepatic cell-spheroid culture or its biological activity, particularly in detoxification function. Here, we constructed a PAMAM-dendrimer conjugate decorated by an integrin ligand: arginine-glycine-aspa...

2016
Qian Zhong K. S. V. Krishna Rao

Polyamidoamine (PAMAM) dendrimers have gained so much attention for drug and gene delivery since they have been introduced decades ago. The internal cavities and multivalent surface groups of PAMAM dendrimers have been widely used for small-molecule drugs/biomacromolecules encapsulation and conjugation. The involvement of PAMAM dendrimers in drug delivery systems (DDSs) has significantly improv...

2009
Malgorzata A. Kaczorowska Helen J. Cooper

The electron capture dissociation (ECD) and collision-induced dissociation (CID) of complexes of polyamidoamine (PAMAM) dendrimers with metal ions Ag(+), Cu(2+), Zn(2+), Fe(2+), and Fe(3+) were determined by Fourier transform ion cyclotron resonance mass spectrometry. Complexes were of the form [PD + M + mH](5+) where PD = generation two PAMAM dendrimer with amidoethanol surface groups, M = met...

2006
C. L. Peng P. S. Lai T.-Y. Lai M. J. Shieh

Starburst polyamidoamine (PAMAM) dendrimer is a new class of highly branched spherical polymer. Covalent attachment of porphyrin to PAMAM dendrimer may alter the pharmacokinetics, cell targeting, and photophysical properties of porphyrin. We investigated the uptake, localization, and phototoxicity of PAMAM-porphyrin conjugate with different charges and hydrophobicity in Hela cell lines. The cel...

2012
Hidetoshi Arima Keiichi Motoyama Taishi Higashi

Gene, short hairpin RNA (shRNA) and small interfering RNA (siRNA) delivery can be particularly used for the treatment of diseases by the entry of genetic materials mammalian cells either to express new proteins or to suppress the expression of proteins, respectively. Polyamidoamine (PAMAM) StarburstTM dendrimers are used as non-viral vectors (carriers) for gene, shRNA and siRNA delivery. Recent...

Journal: :Advanced functional materials 2010
Hye Jung Han Rangaramanujam M Kannan Sunxi Wang Guangzhao Mao Juan Pedro Kusanovic Roberto Romero

Dendrimers, with their well-defined globular shape and a high density of functional groups, are ideal nanoscale materials for templating sensor surfaces. This work exploits dendrimers as a versatile platform for capturing biomarkers with improved sensitivity and specificity. Synthesis, characterization, fabrication, and functional validation of the dendrimer-based assay platform are described. ...

Journal: :Nanoscale 2015
Panagiotis Mastorakos Siva P Kambhampati Manoj K Mishra Tony Wu Eric Song Justin Hanes Rangaramanujam M Kannan

Ocular gene therapy holds promise for the treatment of numerous blinding disorders. Despite the significant progress in the field of viral and non-viral gene delivery to the eye, significant obstacles remain in the way of achieving high-level transgene expression without adverse effects. The retinal pigment epithelium (RPE) is involved in the pathogenesis of retinal diseases and is a key target...

Background: Dendrimers are a subset of branched structures that have certain structural order. The aim of this study was to investigate the performance of Nano Polyamidoamine–G5 (NPAMAM-G5)  dendrimers in removal of Escherichia Coli, Salmonella Typhi, Shigella Dysenteriae and Bacillus Subtilis from aqueous solution. Material and methods: In this experimental study, initially dilut...

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