Routine and mass administration of oral polio vaccine (OPV) since 1961 has prevented many millions of cases of paralytic poliomyelitis. The public health value of this inexpensive and easily administered product has been extraordinary. Progress of the Global Polio Eradication Initiative has further defined the value of OPV as well as its risk through vaccine-associated paralytic poliomyelitis (...

The simultaneous administration of B.C.G. vaccine, diphtheria-tetanus toxoid aluminium hydroxide adsorbed vaccine, and oral poliovaccine was studied in 628 children aged 13-14 years between 1966 and 1969 in Newham, London. The efficacy of these vaccines was unaffected by administering them at the same time; routine simultaneous administration is considered justified when organizational difficul...

A benefit-cost analysis of the Poliomyelitis Eradication Initiative was undertaken to facilitate national and international decision-making with regard to financial support. The base case examined the net costs and benefits during the period 1986-2040; the model assumed differential costs for oral poliovirus vaccine (OPV) and vaccine delivery in industrialized and developing countries, and igno...

In 2000 and 2001 there were 265 and 268 virologicallyconfirmed polio cases respectively, in India. In 2002 the number increased to 1,600. In response to some questions raised by the author (1), Dr Jay Wenger, project manager of the National Polio Surveillance Project of the WHO (NPSP-WHO), stated: “...the outbreak of 2002 and the problems of polio eradication were not caused by the failure of O...

the development and widespread use of a prophylactic vaccine significantly reduced the incidence of poliomyelitis. at present we more commonly encounter with poliomyelitis sequelae especially in developing countries. we evaluate the results of a modified innominate osteotomy for leg length discrepancy in poliomyelitis. instead of triangular bone graft as in salter’s innominate osteotomy , a tra...

BACKGROUND In 1988 the World Health Assembly adopted the goal to eradicate poliomyelitis by routine immunization using Oral Polio Vaccine (OPV). On 21 June 2002 the WHO European Region was declared polio-free. In 2008 poliomyelitis is still endemic in 4 countries (Nigeria, India, Pakistan, and Afghanistan), where 1201 new cases were registered in 2007; 107 sporadic cases were also notified in c...

written with such clarity that readers who are not familiar with the field should have little or no difficulty understanding the material presented. Of particular current interest are the final three papers which deal with immunization against poliomyelitis. Dr. Albert Sabin presents a clear picture of present concepts of the pathogenesis of poliomyelitis (documented by careful investigation) w...

A retrospective study to identify VAPP cases from the entire Uganda was conducted between January 2003 and December 2011. Eleven of the 106 AFP cases were VAPPs. The VAPP rate ranged from 0 to 3.39 cases per 1,000,000 birth cohorts and the peak was in 2009 when there was scaling up of OPV immunization activities following an importation of wild poliovirus in the country. All the subsequent poli...