Podophyllum species are sources of (-)-podophyllotoxin, an aryltetralin lignan used for semi-synthesis of various powerful and extensively employed cancer-treating drugs. Its biosynthetic pathway, however, remains largely unknown, with the last unequivocally demonstrated intermediate being (-)-matairesinol. Herein, massively parallel sequencing of Podophyllum hexandrum and Podophyllum peltatum ...

INTRODUCTION The American mayapple (Podophyllum peltatum L.; Berberidaceae) is a rhizomatous perennial species found throughout eastern North America. The species has received attention recently due to pharmaceutical compounds found in its leaves. Podophyllotoxin, along with α-peltatin, and β-peltatin, are aryltetralin lignans known to have biological activity such as anti-cancer, anti-fungal, ...

The first enantioselective synthesis of 4-aza-podophyllotoxin derivatives by partial transfer hydrogenation of lactone-fused quinolines was achieved using a chiral Brønsted acid catalyst. This reaction was extended to a large scope of substrates with good yields and enantioselectivities.

OBJECTIVE To compare the effectiveness and cost of self treatment of penile warts with a commercial preparation of podophyllotoxin 0.5% (PDX 0.5%) with podophyllin 0.5% and podophyllin 2.0% sourced from Podophyllum emodii. DESIGN A prospective double blind randomised study. SUBJECTS 315 patients with penile warts attending two departments of genitourinary medicine. MAIN OUTCOME MEASURES A...

The distribution of microtubules in Chlamydomonas reinhardtii suggests that they are involved in mitosis, cell and nuclear cleavage, and generation of flagella. Vinblastine, colchicine, and podophyllotoxin bind to the protein building block of microtubules (tubulin) and prevent normal assembly. Mutants resistant to these "antitubulin" drugs are candidates to have alterations in tubulin primary ...

Sinopodophyllum emodi is a herbaceous perennial plant. It is used in the treatment of hemopathy, retained placenta and lochiorrhea. Its root contains podophyllotoxin, which has an anti-tumor effect. Compounds were isolated by column chromatography, and were analyzed by NMR chromatography; flow cytometry was used to determine the anticancer activity of ethanol extract of Sinopodophyllum emodi. T...

The effects of the anticancer drugs 4'-demethylepipodophyllotoxin thenylidene /3-o-glucoside and 4'-demethylepipodophyllotoxin ethylidene 0-o-glucoside on the growth and viability of Chinese hamster ovary cells have been examined. Stable mu tants which are from 4to 12-fold more resistant to these drugs (VpmR mutants) are obtained in a single selection step in Chinese hamster ovary cells at a fr...

This study aimed to investigate the antifertility effect of Juniperus sabina fruit on male rats and its possible mechanism, and hence it might be developed as a potential nonhormonal male contraceptive. Male rats were intragastrically fed for consecutive 8-week and 4-week recovery with the fruit of J. Sabina, and sperm maturation, serum testosterone level, and histopathology were analyzed. Epid...