OBJECTIVE To assess the relationship between periodontal treatment needs by elderly Brazilians and contextual as well as individual variables. METHODS A cross-sectional study was carried out to assess the need for clinical periodontal treatment, based on National Oral Health Survey (SB Brasil 2010) data on the presence of dental calculus, shallow (3-5 mm) and deep (≥ 6 mm) periodontal pockets...

OBJECTIVES The aim of the study was to investigate the clearance of PVP-iodine applied as a gel or solution in periodontal pockets. METHODS Teeth of 12 subjects with at least eight periodontal pockets of �5 mm probing depth were isolated with a rubber dam to allow contamination-free access to the pockets. In each subject, three pockets were filled with PVP-iodine gel (10%) and three with PVPiod...

The intrinsic ability of protein structures to exhibit the geometric and sequence properties required for ligand binding without evolutionary selection is shown by the coincidence of the properties of pockets in native, single domain proteins with those in computationally generated, compact homopolypeptide, artificial (ART) structures. The library of native pockets is covered by a remarkably sm...

The results of imbedding cellophane subcutaneously in rats were compared with previous results with polystyrene; 280 films were imbedded subcutaneously in 140 rats, which were divided into three groups and observed for tumor incidence. All animals were permitted to live out their life span. Group I: Films were removed at monthly intervals from the enveloping pockets induced. Group II : Pockets ...

T effects of local drug delivery to the subgingival plaque flora using resorbable base material were evaluated by the study of microbial composition in periodontal pockets and clinical manifestations of disease. Jn vitro, the drug used in this study was released within 24 hr from the hydroxypropylcellulose (HPC) strips. In vivo release of the drug from strips was also measured in nine patients ...

MOTIVATION Identification of ligand binding pockets on proteins is crucial for the characterization of protein functions. It provides valuable information for protein-ligand docking and rational engineering of small molecules that regulate protein functions. A major number of current prediction algorithms of ligand binding pockets are based on cubic grid representation of proteins and, thus, th...

Protein-protein and protein-ligand interactions are ubiquitous in a biological cell. Here, we report a comprehensive study of the distribution of protein-ligand interaction sites, namely ligand-binding pockets, around protein-protein interfaces where protein-protein interactions occur. We inspected a representative set of 1,611 representative protein-protein complexes and identified pockets wit...

We show the nonexistence of deep pockets in a large class of groups, extending a result of Bogopol’skĭi. We then give examples of important groups (namely lattices in Nil and Sol) which have deep pockets.

The set of peptides that is bound by a given major histocompatibility complex class I product can be described by one or two properly spaced anchor residues, and two properly spaced peptide termini, approximately 8-10 residues apart. Using radiolabeled peptide libraries, we examined whether mutations in those "pockets" in class I Kb molecules that do not seem critically involved in the interact...