We report a catalytically promiscuous enzyme able to efficiently promote the hydrolysis of six different substrate classes. Originally assigned as a phosphonate monoester hydrolase (PMH) this enzyme exhibits substantial second-order rate accelerations ((k(cat)/K(M))/k(w)), ranging from 10(7) to as high as 10(19), for the hydrolyses of phosphate mono-, di-, and triesters, phosphonate monoesters,...

Im Projekt FIS-I, das vom Bundesministerium für Bildung und Forschung (BMBF) gefördert wird, soll der Zugriff auf Informatik-Literatur zentralisiert werden. Die Projektpartner Universtät Karlsruhe (Collection of Computer Science Bibliographies) und TU München(LEABiB) stellen hierfür die bibliographischen Daten bereit. In diesem Beitrag werden die praktischen Erfahrungen vorgestellt, die bei der...

Purpose – To examine the relationship between deposit of electronic theses in institutional and archival repositories. Specifically the paper considers the automated export of theses for deposit in the archival repository in continuation of the existing arrangement in Wales for paper-based theses. Design/methodology/approach – The paper presents a description of software that makes use of the O...

Menopause is reported to be associated with increased urinary calcium excretion, which may enhance the risk for the development of calcium kidney stones. However, it remains controversial about whether high level of postmenopausal hormone (PMH) is a risk factor for formation of nephrolithiasis. Several observational studies have shown that PMH is protective based on 24-hour urinary parameters. ...

Obesity has consistently been associated with increased colorectal cancer risk in men, but not in women. In the absence of postmenopausal hormone use (PMH), adipose-derived estrogen is the primary determinant of circulating estrogen levels in postmenopausal women, perhaps ameliorating the mitogenic effects of obesity in this group. Using data from a case-control study in the United States, we e...

This paper focuses on the multifaceted use of the OAI-PMH in a repository architecture designed to store digital assets at the Research Library of the Los Alamos National Laboratory (LANL), and to make the stored assets available in a uniform way to various downstream applications. In the architecture, the MPEG-21 Digital Item Declaration Language is used as the XML-based format to represent co...

The Web Services paradigm for distributed computing promises to provide a breakthrough in interoperability by defining standardised mechanisms for inter-process communication. The SOAP standard, in particular, is widely discussed but not as widely adopted by standards bodies. The OAI is one such organisation that has been criticised for not adopting SOAP. Since the OAI-PMH is driven by semantic...

The North Pacific marine heatwave of 2014–2016 (PMH), one the most geographically-extensive and severe heatwaves on record, resulted in widespread persistent perturbation Gulf Alaska California Current ecosystems. Negative effects PMH mammals have been observed, but are not yet well understood. endangered Steller sea lion Eumetopias jubatus is an important top predator that also particularly vu...

The paper deals with the necessity of systemic solution for metadata providing by local archives into central repositories and its subsequent implementatiton by the Department of Information Technologies, Faculty of Economics and Management, Czech University of Life Sciences in Prague, for the needs of the agrarian WWW AGRIS portal. The system supports the OAI-PMH (Open Archive Initiative – Pro...