A new kind of high-quality Ag/PS coaxial nanocables can be facilely synthesized by using soft/hard templates method. In order to effectively introduce Ag sources into porous polystyrene (PS) nanotubes which were trapped in porous anodic aluminum oxide (AAO) hard template, Pluronic F127 (F127) was used as guiding agent, soft template and reductant. Meanwhile, ethylene glycol solution was also us...

Excellent electrophoretic separations of a variety of biological molecules can be accomplished by using uncharged, triblock copolymers as the "gel" media. These copolymers form uncrosslinked, lyotropic liquid crystalline phases of large micelles between which molecules must travel. Unlike crosslinked hydrogels in common use, these alternative media have highly ordered internal structures. Pluro...

ABSTRACT The objective of this study was to develop a novel subgingival sustained-release system for local delivery bioactive minocycline hydrochloride periodontal disease treatment in dogs. incorporated the Minocycline hydrochloride-Calcium-Dextran sulfate sodium into thermoresponsive Pluronic F127 hydrogel. sustained release from up 10 days and kinetics fit power law model. medium had signifi...

The production of an intramuscular (IM) injection of natural progesterone would provide a safer solution than using semi synthetic progesterone. However, disadvantages such as low solubility and a short half life prevent the use of natural progesterone. In this study, we formulated a sustained release form of natural progesterone to be given as IM injection. A progesterone nanosuspension (PNS) ...

Novel pH-sensitive gel-forming pentablock copolymers based on commercially available Pluronic (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide), PEO-b-PPO-b-PEO) triblock copolymers and cationic diblock copolymers based on polyethylene glycol) methyl ether (PEGME) were synthesized by oxyanionic polymerization. Polymerization of the cationic moiety, poly((diethylamino)-ethyl m...

Cervical cancer is a leading cause of death among women. The endocervical adenocarcinoma (ECA) represents an aggressive and metastatic type with no effective treatment options currently available. We evaluated the antitumoral anti-migratory effects hypericin (HYP) encapsulated on Pluronic F127 (F127/HYP) photodynamic therapy (PDT) against human cell line derived from invasive cervical (HeLa) co...

The therapeutic effect of methotrexate (MTX)-conjugated Pluronic-based polymeric mixed micelles (F127/P105-MTX) on the folate receptor-overexpressing tumors treatment was investigated in this study. Due to its high structural similarity to folic acid and the high expression of folate receptor in most solid tumors, MTX serves as not only a cytotoxic agent but also a homing ligand. Cellular uptak...

The bibliometric data were extracted from the Scopus database to investigate conceptual framework of ocular nanoemulsion and/or in-situ gel drug delivery system using “ocular” AND “nanoemulsion” OR “in-situ gel” keywords. evaluated with RStudio and VOSviewer program. results reveal that publication trends tend increase continually. India is most impactful country, constructive institution Depar...

Pluronic/bile salt/phospholipid mixed micelles (Pluronic/BS/PS-MM) drug carrier system for solubilization hydrophobic drugs was developed. A typical hydrophobic compound, pyrene, was selected as a representative hydrophobic compound to model the hydrophobic drugs. Five Pluronics, F68, F88, F98, F108, and F127 with different PPO chain length were studied. CMC data and solubilization capacities w...