Pluronic micelles represent a novel type of nanocarriers that enhance the therapeutic efficacy of paclitaxel (PTX) by increasing its solubility and circulation time. However, encapsulation or incorporation of a drug influences the micellar structure and subsequently alters the pharmacokinetic behavior of the drug delivery system. In this study, we investigated the structural properties of micel...

In order to get a better understanding of amoeba-substrate interactions in the processes of cellular adhesion and directional movement, we engineered glass surfaces with defined local adhesion characteristics at a micrometric scale. Amoeba (Dictyostelium dicoideum) are capable to adhere to various surfaces independently on the presence of extracellular matrix proteins. This paper describes the ...

To advance emulsion droplet technology, we synthesize functional derivatives of Pluronic F127 that can simultaneously act as surfactants and as reactive sites for droplet surface decoration. The amine-, carboxyl-, N-hydroxysuccinimide ester-, maleimide- and biotin-terminated Pluronic F127 allows ligand immobilization on single-emulsion or double-emulsion droplets via electrostatic adsorption, c...

A major function of the enterocytes is absorption, processing, and export of dietary lipids into the lymphatic system. Pluronic L-81 is a non-ionic hydrophobic surfactant, which specifically inhibits lipid absorption in the intestine when administered in vivo. This compound is therefore an attractive probe to perturb and investigate the molecular and intracellular events in chylomicron assembly...

Facile, one-step synthesis of self-assembling, cationic block copolymers of poly(2-N-(dimethylaminoethyl) methacrylate) (pDMAEMA) and PEO-PPO-PEO (Pluronic®) is developed. The copolymers are obtained via free-radical polymerization of DMAEMA initiated by Pluronic-radicals generated by cerium (IV). The copolymers possess surface activity, are polycationic at pH<7.1, and self-assemble into micell...

objective(s):despite of wide range applications of polymeric nanoparticles in protein delivery, there are some problems for the field of protein entrapment, initial burst and controlled release profile.   materials and methods: in this study, we investigated the influence of some changes in plga nanoparticles formulation to improve the initial and controlled release profile. selected parameters ...

Here, we produce poly(lactide-co-glycolide) (PLGA) based microparticles with varying morphologies, and temperature responsive properties utilizing a Pluronic F127/dextran aqueous two-phase system (ATPS) assisted self-assembly. The PLGA polymer, when emulsified in Pluronic F127/dextran ATPS, forms unique microparticle structures due to ATPS guided-self assembly. Depending on the PLGA concentrati...

A large number of studies have shown that bufalin can have a significant antitumor effect in a variety of tumors. However, because of toxicity, insolubility in water, fast metabolism, short half-life, and other shortcomings, its application is limited in cancer therapy. In this study, we explored the anti-metastatic role of bufalin-loaded pluronic polyetherimide nanoparticles on HCT116 colon ca...

Our previous studies have demonstrated that surfaceactive copolymers of Pluronic® surfactants and tertiary amino polycations such as poly (2-dimethylaminoethyl methacrylate) (PDMA) possess an enhanced DNA transfection efficiency compared to PDMA homopolymers. In order to understand the mechanism of such action, we conducted model studies of the interaction of polymer with phospholipid vesicles ...

Demineralized bone matrix (DBM) is widely used for bone regeneration. Since DBM is prepared in powder form its handling properties are not optimal and limit the clinical use of this material. Various synthetic and biological carriers have been used to enhance the DBM handling. In this study we evaluated the effect of gamma irradiation on the physical-chemical properties of Pluronic and on bone ...