Platelet concentrates have been used in various applications within Oral and Maxillofacial Surgery and Implantology with the aim of promote tissue repair. The first generation of platelet concentrates is Platelet-Rich Plasma (PRP) and recent studies question its actual effectiveness on tissue healing because of the rapid release of growth factors. The second generation of platelet concentrates,...

background: activated platelets shed microparticles (mps) in vivo and certainly in vitro under storage. like platelets, platelet-derived mps contribute to hemostatic and inflammatory responses. we sought to determine the interactions between platelet mps and peripheral b lymphocytes in the healthy blood circulation to propose a possible role for platelet mps in the functioning of b cells.   mat...

A series of indole-based aryl(aroyl)hydrazone analogs of antiplatelet indole-3-carboxaldehyde phenylhydrazone were synthesized by the Schiff base formation reaction and their antiplatelet activity was assessed using human platelet rich plasma. The platelet concentrate was obtained using a two-step centrifugation protocol and ADP, arachidonic acid and collagen were used as inducers of platelet a...

Platelet concentrates, which are enriched with growth factors well-known to boost the healing process and have started be in trend utilized clinically periodontal surgical procedures. Its autologous nature provides an advantage patients as it reduces treatment cost minimizes risk of cross-infection. Despite its exclusive application promoting healing, there is data paucity on role platelet conc...