نتایج جستجو برای: plasminogen activator

تعداد نتایج: 52174  

2017
Shih-Jen Tsai

Major depressive disorder is a common illness worldwide, but the pathogenesis of the disorder remains incompletely understood. The tissue-type plasminogen activator-plasminogen proteolytic cascade is highly expressed in the brain regions involved in mood regulation and neuroplasticity. Accumulating evidence from animal and human studies suggests that tissue-type plasminogen activator and its ch...

Journal: :Haematologica 2012
Romaric Lacroix Laurent Plawinski Stéphane Robert Loïc Doeuvre Florence Sabatier Sara Martinez de Lizarrondo Anna Mezzapesa Francine Anfosso Aurelie S Leroyer Pascale Poullin Noémie Jourde Makon-Sébastien Njock Chantal M Boulanger Eduardo Anglés-Cano Françoise Dignat-George

BACKGROUND We recently assigned a new fibrinolytic function to cell-derived microparticles in vitro. In this study we explored the relevance of this novel property of microparticles to the in vivo situation. DESIGN AND METHODS Circulating microparticles were isolated from the plasma of patients with thrombotic thrombocytopenic purpura or cardiovascular disease and from healthy subjects. Micro...

Journal: :The Journal of antibiotics 1999
C Shinohara K Hasumi T Chikanishi T Kikuchi A Endo

the regulation of fibrinolysis in the blood vessel by producing plasminogen activators and plasminogen activator inhibitors. Defects in physiological regulation of the balance of the activities between plasminogen activator and the inhibitors may cause vascular diseases such as thromboembolismand atherosclerosis. In patients with such diseases, the inhibitor may be dominant in this balance. Act...

Journal: :The Journal of Experimental Medicine 1975
J K Christman S C Silverstein G Acs

Rabbits were immunized against the plasminogen activator released by SV4- virus-transformed hamster embryo cells. The resulting antiplasminogen activator immunoglobulin (APA-IgG) inhibited the enzymatic activity of the plasminogen activator produced by SV40-transformed hamster cells, and the plasmin-catalyzed release of these cells from the tissue culture dish. APA-IgG was not cytotoxic for t...

Journal: :Arteriosclerosis: An Official Journal of the American Heart Association, Inc. 1988

2016
Haseeb A. Khan

AMI: Acute Myocardial Infarction; aPTT, Activated Partial Thromboplastin Time; CCSP: Clinical Coronary Stenosis Progression; CK: Creatine Kinase; CRP: C-reactive Protein; CVD: Cerebrovascular Disease; CVP: Cerebral Vasculopathies; HDL: High Density Lipoprotein; LDL: Low Density Lipoprotein; Lp(a): Lipoprotein (a); MACE: Major Adverse Cardiac Event; PAI-1: Plasminogen Activator Inhibitor-1; PT: ...

Journal: :Japanese Journal of Thrombosis and Hemostasis 1990

Journal: :Blood 1989
J C Kirchheimer H G Remold

We compared urokinase-type plasminogen activator (u-PA) in fluid phase and u-PA bound with its receptor on human blood monocytes with respect to proteolytic activity and susceptibility to inactivation by the plasminogen activator inhibitors PAI-1 and PAI-2. Receptor-bound u-PA is catalytically twice as efficient as fluid-phase u-PA. Fluid-phase u-PA is susceptible to rapid inhibition by PAI-1 a...

Journal: :Stroke 1992
T G Brott E C Haley D E Levy W Barsan J Broderick G L Sheppard J Spilker G L Kongable S Massey R Reed

BACKGROUND AND PURPOSE Thrombolytic agents hold theoretical promise as therapy for cerebral infarction. This study was designed to evaluate the safety of tissue plasminogen activator, to accomplish urgent patient treatment, and to estimate potential efficacy of tissue plasminogen activator. METHODS Following neurological evaluation and computed tomography of the brain, patients with acute isc...

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