Purpose. The present study was designed to investigate the antinociceptive, anxiolytic, CNS depressant, and hypoglycemic effects of the naproxen metal complexes. Methods. The antinociceptive activity was evaluated by acetic acid-induced writhing method and radiant heat tail-flick method while anxiolytic activity was evaluated by elevated plus maze model. The CNS depressant activity of naproxen ...

The properties of Ehrlich ascites tumour cells exposed in vivo to cadmium were investigated as a function of the zinc status of the host animals. Tumour-cell growth was inhibited by cadmium in both zinc-sufficient and zinc-deficient animals. However, cells in zinc-sufficient tumours accumulate much less cadmium than those in deficient tumours. The subcellular distributions of cadmium and zinc d...

Introduction: Zinc and copper are essential for normal human development and functioning of the body. They have been implicated to play important roles in immuno-physiologic functions. Studies assessing the interactions between diarrheal diseases, HIV/AIDS and micronutrient status are too few in Ethiopia, as in other sub-Saharan Africa where morbidities from diarrheal diseases and HIV/AIDS are ...

Many studies have reported that zinc plasma levels significantly decrease after a burn, leading to zinc deficiency, and that increased free radical generation and decreased natural antioxidant may negatively affect wound healing and burn outcome in general. Targeting of these changes is considered an important strategy in the treatment of burns in an attempt to improve burn outcome in the clini...

A method for the speciation of zinc and copper binding with proteins in human serum was explored by chelating resin (Chelex-100) pre-treatment and inductively coupled plasma mass spectrometry (ICP-MS). It was shown by a SEC (size-exclusion chromatography)-ICP-MS system that albumin-zinc and albumin-copper (loosely-bound species) could be selectively removed from serum by adsorption on the Chele...

Ion chromatography was used to detect levels of copper and zinc in blood plasma from renal dialysis patients on continuous ambulatory peritoneal dialysis (CAPD) and haemodialysis (HD). The developed method used cobalt as an internal standard and when combined with the standard additions method improved the overall precision of the results by between -0.3 and 6.0% and -0.8 and 5.7% for copper an...

OBJECTIVE To describe a patient with idiopathic zinc overload without an identifiable source and secondary copper deficiency causing myelopolyneuropathy and pancytopenia. DESIGN Case report. PATIENT AND RESULTS A 46-year-old man presented with severe bone marrow suppression and subsequently developed progressive myelopathy with sensory ataxia. No identifiable cause of myelopathy was detecte...

BACKGROUND Resveratrol, which belongs to a class of polyphenolic compounds called stilbenes, is proposed to have anti-aging effects. OBJECTIVES This research has focused on the effects of resveratrol on oxidant/antioxidant systems and also copper and zinc concentrations in rats. MATERIAL AND METHODS The control group consisted of 12 male Wistar albino rats, 10-12 weeks of age, weighing appr...

BACKGROUND Hemodialysis patients are at risk for deficiency of essential trace elements and excess of toxic trace elements, both of which can affect health. We conducted a systematic review to summarize existing literature on trace element status in hemodialysis patients. METHODS All studies which reported relevant data for chronic hemodialysis patients and a healthy control population were e...

BACKGROUND As breast milk micronutrients content are essential for health and growth of the infants, this study was conducted to determine the breast milk zinc, copper and iron concen-trations and their possible correlations with maternal nutritional status, dietary intakes as well as socioeconomic status. METHODS Breast milk samples and information on maternal anthropometric characteristics ...