Cardiovascular disease, in particular coronary artery disease (CAD), remains the most important cause of morbidity and mortality in developed countries and, in the near future, more so in the developing world. Atherosclerotic plaque formation is the underlying basis for CAD. Growth of the plaque leads to coronary stenosis, causing a progressive decrease in blood flow that results in angina pect...

Lipid-rich atherosclerotic plaques are vulnerable, and their rupture can cause the formation of a platelet- and fibrin-rich thrombus leading to myocardial infarction and ischemic stroke. Although the role of plaque-based tissue factor as stimulator of blood coagulation has been recognized, it is not known whether plaques can cause thrombus formation through direct activation of platelets. We is...

We use a computational model to explore the effect of foam cell accumulation on plaque regression following an increase in high density lipoprotein (HDL) influx into the plaque. Atherosclerotic plaque formation is the outcome of cellular and cytokine responses to low density lipoproteins (LDL) that penetrate the artery wall following an injury to the endothelium and become modified. We modelled...

The role of microglia in amyloid-β (Aβ) deposition is controversial. In the present study, an organotypic hippocampal slice culture (OHSC) system with an in vivo-like microglial-neuronal environment was used to investigate the potential contribution of microglia to Aβ plaque formation. We found that microglia ingested Aβ, thereby preventing plaque formation in OHSCs. Conversely, Aβ deposits for...

Smull, Christine E. (The Geisinger Medical Center, Danville, Pa.), and E. H. Ludwig. Infectivity of poliovirus and its nucleic acid for dehydrated HeLa cell monolayers. J. Bacteriol. 89:52-57. 1965.-A study was made of the infectivity of poliovirus ribonucleic acid (RNA), applied in various diluents, and of poliovirus, on cell monolayers which were washed free from their nutrient medium and all...

BACKGROUND AND PURPOSE Activation of monocytes and differentiation into lipid-laden macrophages are fundamental events in generation of atherosclerotic lesions. There exist few data on monocyte activity and the risk for atherosclerosis. In this prospective population-based study, we examined whether monocyte count in blood is a predictor of future plaque formation in persons without pre-existin...

Formation of atherosclerotic and calcified plaque begins and grows up not only beneath the endothelium (intimae), but also in the adventitial subepithelium on the coronary arteries. A new innovative combined drug (polypill) is certainly releases, regress and prevents of formation of the atherosclerotic and calcified plaque of arteries.

conclusions similar to previous studies, this study could not show the superiority of electric toothbrush over manual in plaque removal. after 72 hours, the mean of plaque index was greater in buccal than in lingual surface, which may be attributed to the natural cleansing action of the tongue. results the mean of plaque index was 2.13 ± 0.83 and 2.11 ± 1.01 in the manual and electric toothbrus...