The high neonatal and maternal morbidity and mortality associated with the extremes of birth weight is referred to as the obstetric dilemma. Pre-eclampsia and other conditions that lead to low birth weight are considered as the Great Obstetrical Syndromes (GOS). At the other extreme is high birth weight resulting in obstructed labour. Fetal weight largely depends on placental function and defec...

Implantation of the embryo in the uterus is a critical and complex event and its failure is widely considered an impediment to improved success in assisted reproduction. Depending on whether placentation is invasive or superficial (epitheliochorial), the embryo may interact transiently or undergo a prolonged adhesive interaction with the uterine epithelium. Numerous candidate interactions have ...

Uterine spiral arteries are extensively remodeled during placentation to ensure sufficient delivery of maternal blood the developing fetus. arterial remodeling is complex, as cells originating from both mother and conceptus interact at interface regulate extracellular matrix vasculature restructuring necessary for successful placentation. Despite this complexity, one mechanism critical artery t...