Abstract Objectives To rule out a drug-drug interaction (DDI) among cangrelor-treated patients who have been pre-treated with ticagrelor. Background There are no studies specifically designed to DDI when cangrelor is used Methods In this prospective, randomized, double-blind, placebo-controlled, cross-over, pharmacokinetic (PK) and pharmacodynamic (PD) study, coronary artery disease (n = 20) we...

AIMS To assess the effect of trandolapril (2 mg once daily) and indomethacin (25 mg three times daily), alone and in combination, on renal function and renal functional reserve in hypertensive patients (DBP 95-115 mmHg) requiring regular non-steroidal anti-inflammatory drugs (NSAIDs). METHODS Randomized, double-blind, placebo-controlled, four way crossover design. After 3 weeks treatment rena...

background opium is a highly addictive agent and the most common narcotic often misused in iran. the pharmacokinetic of anesthetic drugs in patients with opium addiction is one of the great challenges for anesthesiologists. hemodynamic instability and postoperative side effects are of these challenges which should be managed correctly. objectives in this study we aimed to assess the effects of ...

atherosclerosis is a chronic inflammatory condition. many pro-inflammatory factors including interleukin-6 (il-6), tumor necrosis factor-α (tnf-α), c-reactive protein (crp), and adhesion molecules including intercellular adhesion molecule (icam-1) and vascular cell adhesion molecule (vcam-1) are expressed in atherosclerotic lesions. the plants of genus vaccinium are rich in anthocyanins with an...

We have studied the effect of oral nizatidine 6 mg kg-1 in total on preoperative gastric fluid pH and volume in children. One hundred and four healthy children, aged 4-11 yr, were allocated randomly to four groups (n = 26): placebo administered at 21:00 and 06:30 the night before and on the day of surgery, respectively (placebo-placebo: control); nizatidine 6 mg kg-1 at 21:00 and placebo at 06:...

In a randomized, head-to-head, placebo-controlled trial, we enrolled adults with obesity (body-mass index [the weight in kilograms divided by the square of height meters], 32 to 43) who did not have diabetes. After an 8-week low-calorie diet, participants were randomly assigned for 1 year one four strategies: moderate-to-vigorous–intensity exercise program plus placebo (exercise group); treatme...

Abstract Background Type 2 diabetes mellitus is closely associated with cardiovascular disease and evidence already exists on its arrhythmogenic action. Sodium-glucose cotransporter inhibitors (SGLT2i) are a unique class of oral antidiabetic medications which recently attracted attention for reducing the total risk major adverse events in series recent, large placebo-controlled randomized clini...

BACKGROUND The placebo effect in relieving negative emotion arousal is poorly understood. AIMS We examined whether placebo expectation established with noise stimuli could have a transferable anxiolytic effect on negative emotion arousal. METHODS In Experiment 1, noise intensity was surreptitiously lowered during placebo condition in the preconditioning phase to reinforce placebo expectatio...

Background and aim: Psoriasis is one of the most common papulosquamous diseases that often requires long-term maintenance therapy. Long-term use of topical corticosteroids on the face and intertriginous areas will increase the risk of steroids side effects such as striae and atrophy development. A safe, effective and inexpensive modality in topical therapy of inverse psoriasis is required...

Roxadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor that increases endogenous erythropoietin and enhances iron utilization. To evaluate the consistency of Hb across studies global geographic regions, we analyzed data from three pivotal Phase 3 trials roxadustat in patients with anemia NDD-CKD. While based on same trial design, were performed by different investigators companie...