نتایج جستجو برای: pla2

تعداد نتایج: 1363  

Journal: :The American journal of physiology 1998
Jane McHowat Michael H Creer

Activation of phospholipase A2(PLA2) and accumulation of lysophosphatidylcholine contribute importantly to arrhythmogenesis during acute myocardial ischemia. We examined thrombin stimulation of PLA2 activity in isolated ventricular myocytes. Basal and thrombin-stimulated cardiac myocyte PLA2 activity demonstrated a distinct preference for sn-1 ether-linked phospholipids with arachidonate esteri...

Journal: :Nucleic acids research 1994
C F Bennett M Y Chiang L Wilson-Lingardo J R Wyatt

Phosphorothioate oligonucleotides were identified which directly inhibited human type II phospholipase A2 (PLA2) enzyme activity in a sequence specific manner. The minimum pharmacophore common to all oligonucleotides which inhibited PLA2 enzyme activity consisted of two sets of three or more consecutive guanosine residues in a row. These oligonucleotides appear to form G quartets resulting in t...

Journal: :Journal of immunology 2005
Jon K Femling William M Nauseef Jerrold P Weiss

Acute inflammatory responses to invading bacteria such as Staphylococcus aureus include mobilization of polymorphonuclear leukocytes (PMN) and extracellular group IIA phospholipase A2 (gIIA-PLA2). Although accumulating coincidentally, the in vitro anti-staphylococcal activities of PMN and gIIA-PLA2 have thus far been studied separately. We now show that degradation of S. aureus phospholipids du...

Journal: :The Journal of biological chemistry 1990
T Nakano O Ohara H Teraoka H Arita

We investigated the effects of glucocorticoids on group II phospholipase A2 (PLA2) expression in rat cultured smooth muscle cells. Both forskolin-induced and tumor necrosis factor (TNF)-induced PLA2 release responses were almost completely blocked by 10 and 100 nM dexamethasone, respectively, as assayed by protein blotting and PLA2 activity assays. Dexamethasone-mediated inhibition of PLA2 rele...

Journal: :Food Chemistry 2021

The antioxidant effect of porcine pancreatic phospholipase A2 (PLA2) was previously demonstrated. Understanding how PLA2 inhibits lipid oxidation promoted by hemoglobin (Hb) is important for its applications in muscle foods. Effects enzyme dose, pH, and calcium ion on the ability to inhibit trout hemoglobin-mediated were investigated washed cod (WCM). Results indicated that required both hydrol...

Journal: :Circulation 2010
Juan P Casas Ewa Ninio Andrie Panayiotou Jutta Palmen Jackie A Cooper Sally L Ricketts Reecha Sofat Andrew N Nicolaides James P Corsetti F Gerry R Fowkes Ioanna Tzoulaki Meena Kumari Eric J Brunner Mika Kivimaki Michael G Marmot Michael M Hoffmann Karl Winkler Winfred März Shu Ye Heide A Stirnadel S Matthijs Boekholdt Kay-Tee Khaw Steve E Humphries Manjinder S Sandhu Aroon D Hingorani Philippa J Talmud

BACKGROUND Higher lipoprotein-associated phospholipase A(2)(Lp-PLA2) activity is associated with increased risk of coronary heart disease (CHD), making Lp-PLA2 a potential therapeutic target. PLA2G7 variants associated with Lp-PLA2 activity could evaluate whether this relationship is causal. METHODS AND RESULTS A meta-analysis including a total of 12 studies (5 prospective, 4 case-control, 1 ...

2015
Jin-Ming Cen Jie Cheng Qing-Yuan Xiong Bai-Qiang Mei Wei-Biao Cai Xi-Li Yang

OBJECTIVE This study explores the correlation between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) and coronary heart disease (CHD) by comparing the level of plasma Lp-PLA2 in the plasma of patients with different types of CHD. METHODS Blood samples were collected from 56 patients diagnosed with CHD by the Department of Cardiology of the First People's Hospital of Foshan and 34 he...

Journal: :The European respiratory journal 2001
J Lindbom A G Ljungman M Lindahl C Tagesson

Phospholipase A2 (PLA2) is a family of enzymes thought to play a key role in inflammation by releasing arachidonic acid for the synthesis of eicosanoids and lysophospholipid for the synthesis of platelet-activating factor. However, the precise contribution of different PLA2 types to the formation of inflammatory lipid mediators in the upper airways is not known and the expression of different P...

Journal: :The British journal of nutrition 2013
Brian T Steffen Lyn M Steffen Shuang Liang Russell Tracy Nancy Swords Jenny Michael Y Tsai

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an independent risk factor for CVD and has been proposed as a marker of vascular inflammation. Polyunsaturated n-3 fatty acids (FA) and several n-6 FA are known to suppress inflammation and may influence Lp-PLA2 mass and activity. The associations of n-3 and n-6 plasma FA with Lp-PLA2 mass and activity were analysed using linear regression an...

2014
Beatriz Díaz-Pollán Vicente Estrada Manuel Fuentes-Ferrer Dulcenombre Gómez-Garré Jesús San Román-Montero

INTRODUCTION HIV-infected patients show an increased risk of cardiovascular disease (CVD). In the general population, lipoprotein-associated phospholipase A2 (Lp-PLA2) appears to be an independent predictor of CVD. We aimed to study associations between Lp-PLA2 plasma levels and other risk factors for CVD in HIV patients. MATERIALS AND METHODS A cross-sectional, comparative study of two serie...

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