The aim of this study was to develop a new polymeric gel that used as a contraceptive system.Polymeric gel has been studied extensively for drug delivery systems. In this article, thermalsensitive poly (DL-lactic acid)-poly (ethylene glycol) poly (DL-lactic acid) (PLA-PEG-PLA) hydrogel was used as an implantable contraceptive system.Aqueous solution of this copolymer fromed a free flowing so at...

The purpose of this investigation was to characterize the in vitro stability and in vivo disposition of paclitaxel in rats after solubilization of paclitaxel into hydrotropic polymeric micelles. The amphiphilic block copolymers consisted of a micellar shell-forming poly(ethylene glycol) (PEG) block and a core-forming poly(2-(4-vinylbenzyloxy)-N,N-diethylnicotinamide) (P(VBODENA)) block. N,N-Die...

Paclitaxel-polylactide (Ptxl-PLA) conjugate nanoparticles, termed as nanoconjugates (NCs), were prepared through Ptxl/(BDI)ZnN(TMS)(2) (BDI = 2-((2,6-diisopropylphenyl)-amido)-4-((2,6-diisopropylphenyl)-imino)-2-pentene)-mediated controlled polymerization of lactide (LA) followed by nanoprecipitation. Nanoprecipitation of Ptxl-PLA resulted in sub-100 nm NCs with monomodal particle distributions...

The objective of this work is to explore a new pathway develop active packaging materials. Currently, controlled release materials have attracted considerable attention in food applications. In study, the thyme essential oil (TEO) was loaded electrospinning porous poly(lactic acid) (PLA) nanofibers and coated with poly(vinyl alcohol)/poly(ethylene glycol) (PVA/PEG) blends for humidity-controlle...

The synergistic effect of nucleating agents and plasticizers on the thermal and mechanical performance of PLA nanocomposites was investigated with the objective of increasing the crystallinity and balancing the stiffness and toughness of PLA mechanical properties. Calcium carbonate, halloysite nanotubes, talc and LAK (sulfates) were compared with each other as heterogeneous nucleating agents. B...

In this study, melt blended compositions of pure PLA with additions polyethylene glycol (PEG) up to 30 wt% were prepared. Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), and thermogravimetric analysis (TGA) used investigate the properties PLA/PEG blends, such as structural, thermal, morphological properties. The results showed that further increments PEG...

Chitosan (CS)-polylacticacid (PLA)-polyethylene glycol (PEG)-gelatin (G) nanoparticles, a novel drug vehicle for the controlled release of an antitubercluosis drug, rifampicin (RIF) was developed and its chemical and biochemical activities were studied by various standard methods. The designed carriers CS, PEG and G nanoparticles were prepared by emulsion solvent evaporation technique, and then...