We examined the effects of citric acid and l-carnitine administration on physical fatigue. In a double-blind, placebo-controlled, 3-way crossover study, 18 healthy volunteers were randomized to oral citric acid (2,700 mg/day), l-carnitine (1,000 mg/day), or placebo for 8 days. The fatigue-inducing physical task consisted of workload trials on a cycle ergometer at fixed workloads for 2 h on 2 oc...

OBJECTIVE To examine the daily life patterns of both pain and fatigue symptoms and objective physical activity (using ambulatory monitoring) in women with symptomatic lower extremity osteoarthritis (OA), and to evaluate how momentary symptoms impact physical activity levels. METHODS Sixty women age >or=55 years (40 with knee or hip OA and 20 matched controls) participated in an observational ...

It is commonly recognized that proinflammatory cytokines in patients with multiple sclerosis (MS) may increasingly cause inflammation. In this regard, the current study was aimed to shed light on the effectiveness of eight-week Pilates training program at interleukin-18 (IL-18) stage, severity of fatigue and balance as well as physical disability in females with MS. This study was a quasi-exper...

There is limited understanding about variables associated with fatigue in late and very late life. The purpose of this study was to explore the longitudinal influences of personality and health behaviors on changes in fatigue. One hundred and seventy-eight participants of the Georgia Centenarian Study were part of this study. Multiple regression analyses were computed to assess the influence of...

Background: Menopause is the termination of a womanchr('39')s menstrual cycle for a year. In this condition, women’s health status declines due to hormonal changes and aging. Physical Activity (PA) is among the best available alternatives for managing menopause-related symptoms without any adverse effects. This study aimed to assess the relationship between PA and symptoms, such as fatigue, dep...

BACKGROUND Both fatigue and reduced physical activity are important consequences of multiple sclerosis (MS). However, their mutual association is poorly understood. OBJECTIVE The objective of the study was to determine the relation between perceived fatigue and home-based recording of motor activity in patients with MS. METHODS Found associations were checked for confounding by age, Expande...

BACKGROUND Fatigue is associated with loss of independence in older adults; however, little is known about optimal treatment or how fatigue manifests in daily life activities. "Fatigability" was recently proposed to clarify the fatigue-activity relationship. The purpose of this study was to present a new measurement method of fatigability and begin to test its validity. METHODS Our sample inc...

conclusions our findings indicate that fatigue and disability may affect a patient’s quality of life. although mobility may affect the overall quality of life in patients with multiple sclerosis, it may also affect the physical health of ms patients. therefore, the identification of factors affecting the quality of life in ms patients may help in predicting the quality of life, and designing a ...