Mycotoxins are naturally occurring toxins produced by certain types of fungi that contaminate food and feed, posing serious health risks to human livestock. This study evaluated the combination blue light with curcumin inactivate Aspergillus flavus spores, its effect on aflatoxin B1 (AFB1) production maintaining carotenoid content in three maize varieties. The was first conducted vitro, spore s...

The purpose of this study was to determine if photosensitization mediated by the fluorescent dye, merocyanine 540, could be used to preferentially kill murine neuroblastoma cells in simulated autologous remission marrow grafts. Simultaneous exposure of Neuro 2a or NB41A3 neuroblastoma cells to merocyanine 540 and white light reduced the concentration of in vitro-clonogenic tumor cells 50,000-fo...

Antimicrobials are widely used in topical formulations as preservatives or as therapeutically active agents. Photosensitization by such compounds has not yet been studied systematically. To identify possible phototoxic properties, antimicrobials (benzyl alcohol, bronopol, chloracetamide, clioquinol, diazolidinyl urea, ethylenediamine dihydrochloride, formaldehyde, glutaraldehyde, imidazolidinyl...

The production of two reactive oxygen species through UV photosensitization of polyhydroxylated fullerene (fullerol) is shown to enhance viral inactivation rates. The production of both singlet oxygen and superoxide by fullerol in the presence of UV light is confirmed via two unique methods: electron paramagnetic resonance and reduction of nitro blue tetrazolium. These findings build on previou...

Severe, or even lethal, cellular damage can follow the conjoint action of a chemical photosensitizer and effective frequencies of the electromagnetic spectrum. The fact that bacteria, as well as other cellular systems, are subject to photosensitization by such compounds as methylene blue was known fifty years ago (Reitz, 1908). The relatively limited number of studies of bacterial photosensitiz...