In the present work, the drug volume fraction profiles of a colored and very soluble drug, buflomedil pyridoxal phosphate, in the gel layer of initially glassy hydroxypropylmethyl cellulose matrices were studied, using image analysis of pictures of the matrices during swelling and release. The goal was to correlate the drug release kinetics with the dynamic behavior of the drug gradient in the ...

The urinary bladder of the fresh-water turtle acidifies its contents by actively transporting H(+) ions across the luminal membrane. It is known that the H(+) transport system is dependent upon oxidative metabolism and the substrate glucose; however, the specific biochemical events resulting in H(+) translocation have not been identified. This study examines the relationship between active H(+)...

Rigidity and Stability for Isometry Groups in Hyperbolic 4-Space by Youngju Kim Advisor: Professor Ara Basmajian It is known that a geometrically finite Kleinian group is quasiconformally stable. We prove that this quasiconformal stability cannot be generalized in 4-dimensional hyperbolic space. This is due to the presence of screw parabolic isometries in dimension 4. These isometries are topol...

Decision Neural Network is a new approach for solving multi-objective decision-making problems based on artificial neural networks. Using inaccurate evaluation data, network training has improved and the number of educational data sets has decreased. The available training method is based on the gradient decent method (BP). One of its limitations is related to its convergence speed. Therefore,...

Coenzyme A (CoA) transport was studied in isolated rat heart mitochondria. Uptake of CoA was assayed by determining [3H]CoA associated with mitochondria under various conditions. Various oxidizable substrates including alpha-ketoglutarate, succinate, or malate stimulated CoA uptake. The membrane proton (delta pH) and electrical (delta psi) gradients, which dissipated with time in the absence of...

The purpose of this study was to evaluate the spatial changes of groundwater phosphate concentrations using geostatistical methods based on data from 10 groundwater wells. One of the conventional tools in decision making on the groundwater management is geostatistical method. To evaluate the spatial changes of phosphate concentrations in groundwater, the universal kriging method with cross-vali...

A rapid resolution reversed-phase high performance liquid chromatographic (RR RP-HPLC) method has been developed and validated for simultaneous determination of haloperidol and six related compounds. Investigated matrix was a laboratory mixture of a therapeutic active substance haloperidol and its six related compounds in concentration ratio 300:1. Experimental design was used during method opt...

Objective: The objective of the study was to develop and evaluate the reverse phase ultra-performance liquid chromatography (RP-UPLC) method for the quantitative determination of potential impurities of rivaroxaban active pharmaceutical ingredient. Method: The method uses a water acquity BEH C8 column (100mm x 2.1 mm, 1.7μm) with mobile phase A consisted, 0.05M diammonium hydrogen phosphate, pH...