Primary hepatic lymphoma (PHL) has rarely been reported in patients with immunosuppression. We herein describe a case of Epstein-Barr virus- (EBV-) positive PHL in a 67-year-old Japanese woman receiving methotrexate (MTX) treatment for rheumatoid arthritis (RA). The patient, who had been receiving MTX therapy for more than 6 years, presented with low-grade fever and abdominal pain. Initial labo...

Allergens and rhinovirus infections are among the most common elicitors of respiratory diseases. We report the construction of a recombinant combination vaccine for allergy and rhinovirus infections based on rhinovirus-derived VP1, the surface protein which is critically involved in infection of respiratory cells, and a nonallergenic peptide of the major grass pollen allergen Phl p 1. Recombina...

T HE PH1 CHROMOSOME, hallmark of chronic myeboid leukemia (CML), is also found in 5% to 20% of acute lymphoblastic leukemias (ALL) and in about 1% of acute nonbymphoblastic leukemias (AN LL).’ Recent studies showed that about half of the Phl-positive ALLs exhibit molecular rearrangements in the 5.8-kb breakpoint cluster region (bcr, or M-BCR-l according to a recently proposed nomenclature)2 of ...

Herbimycin A, a benzoquinoid ansamycin antibiotic, was demonstrated t o decrease intracellular phosphorylation by protein tyrosine kinase (PTK). In Philadelphia chromosome (Phl)-positive leukemias such as chronic myelogenous leukemia (CML) and Phl-positive acute lymphoblastic leukemia (ALL), both of which express bcr-ab1 fused gene products (P2106cr-a*/ or P1906cr-ab/ protein kinase) with augum...

To investigate the biodisponibility of placental transfer of fatty acids, rats pregnant for 20 days were given tracer amounts of [(14)C]palmitic (PA), oleic (OA), linoleic (LA), α-linolenic (LNA), or docosahexaenoic acid (DHA) orally and euthanized at 0.5, 1.0, 2.0, or 8.0 h thereafter. Maternal plasma radioactivity in lipids initially increased only to decline at later times. Most of the label...

BACKGROUND Specific immunotherapy via the subcutaneous or oral route is associated with local and, in some cases, systemic side effects and suffers from low patient compliance. Due to its unique immunological features, the skin represents a promising target tissue for effective and painless treatment of type I allergy. The current study was performed to compare the efficacy of transcutaneous im...

We report the three-dimensional structure of the complex between the major respiratory grass pollen allergen Phl p 2 and its specific human IgE-derived Fab. The Phl p 2-specific human IgE Fab has been isolated from a combinatorial library constructed from lymphocytes of a pollen allergic patient. When the variable domains of the IgE Fab were grafted onto human IgG1, the resulting Ab (huMab2) in...

Chloroplast-encoded NDH polypeptides (components of the plastid Ndh complex) and the NADH dehydrogenase activity of the Ndh complex (NADH-DH) increased under photooxidative stress. The possible involvement of H2O2-mediated signaling in the photooxidative induction of chloroplastic ndh genes was thoroughly studied. We have analyzed the changes in the NADH-DH and steady-state levels of NDH-F poly...

Understanding the environmental factors that regulate the biosynthesis of antimicrobial compounds by disease-suppressive strains of Pseudomonas fluorescens is an essential step toward improving the level and reliability of their biocontrol activity. We used liquid culture assays to identify several minerals and carbon sources which had a differential influence on the production of the antibioti...

Primary hepatic leiomyoma (PHL) is a rare entity, with very few cases reported in the literature. Even more rarely, until now practically undescribed, transformation of into leiomyosarcoma pancreatic metastases. Here, we report single case progression PHL primary leiomyosarcoma, clinical–surgical and histopathological features, conducted review literature related that can be found.