New low-lying excitations are observed by inelastic light scattering at filling factors nu=p/(phip+/-1) of the fractional quantum Hall regime with phi=4. Coexisting with these modes throughout the range nu < or =1/3 are phi=2 excitations seen at 1/3. Both phi=2 and phi=4 excitations have distinct behaviors with temperature and filling factor. The abrupt first appearance of the new modes in the ...

The contribution of Cl-/HCO3- exchange to intracellular pH (pHi) regulation in cultured chick heart cells was evaluated using ion-selective microelectrodes to monitor pHi, Na+ (aiNa), and Cl- (aiCl) activity. In (HCO3- + CO2)-buffered solution steady-state pHi was 7.12. Removing (HCO3- + CO2) buffer caused a SITS (0.1 mM)-sensitive alkalinization and countergradient increase in aiCl along with ...

Histone deacetylase (HDAC) inhibitors are a new class of chemotherapeutic agents. Our laboratory has recently reported that phenylhexyl isothiocyanate (PHI), a synthetic isothiocyanate, is an inhibitor of HDAC. In this study we examined whether PHI is a hypomethylating agent and its effects on myeloma cells. RPMI8226, a myeloma cell line, was treated with PHI. PHI inhibited the proliferation of...

The mechanism of resistance of murine macrophages (M phi) to infection by herpes simplex virus type 1 (HSV-1) was examined. Infection of bone marrow-derived M phi (BMDM phi) and resident peritoneal M phi (Res-M phi) was compared with infection of permissive Vero cells. In contrast to HSV-1 infection in Vero cells, no infectious virus was produced from either M phi cell type. However, marked cyt...

The growth of ‘Ridge Pineapple’ sweet orange [Citrus sinensis (L.) Osbeck] seedlings and their susceptibility to Phytophthora root rot were studied under contrasting supplies of phosphate (Pi) or Phosphite (Phi). After 10 weeks of repeated applications of nutrient solutions, Phi concentrations were barely detectable in soil. Soil Pi was higher in Phi treatments than in pots that received Pi alo...

Progressive hemorrhagic injury (PHI) can be divided into coagulopathy-related PHI and normal coagu- lation PHI. Coagulation disorders after traumatic brain injuries can be included in trauma-induced coagulopathy (TIC). Some studies showed that TIC is associated with PHI and increases the rates of disability and mortality. In this review, we discussed some mechanisms in TIC, which is of great im...

We numerically study the vibrations of jammed packings of particles interacting with finite-range, repulsive potentials at zero temperature. As the packing fraction phi is lowered towards the onset of unjamming at phi(c), the density of vibrational states approaches a nonzero value in the limit of zero frequency. For phi >phi(c), there is a crossover frequency, omega* below which the density of...

Kidney tubular epithelial cell (TEC) death may be dependent on the number and activation state of macrophages (M phi) during inflammation. Our prior studies indicate that activated M phi release soluble mediators that incite TEC death, and reducing intrarenal M phi during kidney disease diminishes TEC apoptosis. CSF-1 is required for M phi proliferation and survival. We hypothesized that in the...

A novel bacteriophage defense system, based on an inducible suicide gene, was challenged with a lactococcal bacteriophage to investigate the potential for phage adaptation. The defense system was encoded by pTRK414H, a high-copy-number replicon encoding a tightly regulated phi 31p trigger promoter fused to the lethal LlaIR+ restriction endonuclease cassette. Repeated transfers of Lactococcus la...

Data are lacking regarding age-related modifications of phase I (PhI) of pulmonary Vo(2) on-kinetics during moderate-intensity exercise. We studied three groups (aged 20-30, 40-50, and 60-70 years) of 10 normal subjects, who underwent one incremental and four below-gas exchange threshold constant-power cardiopulmonary exercise tests. Data from constant-power tests were time-aligned and averaged...