نتایج جستجو برای: phenformin
تعداد نتایج: 275 فیلتر نتایج به سال:
Case history The patient was a 47-year-old woman who developed diabetes mellitus in 1965. She was initially controlled on chlorpropamide and phenformin. However, her diabetic control became less satisfactory and insulin therapy was substituted in October 1967. Subsequently her diabetes became unstable and phenformin 100-150 mg daily was added in November 1968. Since then her blood glucose level...
A bioassay of the carcinogenicity of phenformin hydrochloride was conducted using Fischer 344 rats and B6C3F1 mice. The compound was administered in the diet for 78 weeks to groups of 35 animals of each species and sex, using concentrations of 15,000 and 30,000 ppm for rats and concentrations of 1,200 and 2,500 ppm for mice. Treatment was followed by a period of observation of 26 weeks. Control...
EARLIER trials at Whittington Hospital confirmed the hypoglycaemic effects of tolbutamide (Wolff, Stewart, Crowley and Bloom, 1956), phenformin (Hall, Crowley and Bloom, 1958) and chlorpropamide (Granville-Grossman, Crawford, Crowley and Bloom, 1959). Since the inception of oral therapy, more than 400 diabetics at this hospital have been successfully treated with these agents for more than thre...
Metformin displays antileukemic effects partly due to activation of AMPK and subsequent inhibition of mTOR signaling. Nevertheless, Metformin also inhibits mitochondrial electron transport at complex I in an AMPK-independent manner, Here we report that Metformin and rotenone inhibit mitochondrial electron transport and increase triglyceride levels in leukemia cell lines, suggesting impairment o...
Metformin, a first-line diabetes drug linked to cancer prevention in retrospective clinical analyses, inhibits cellular transformation and selectively kills breast cancer stem cells (CSCs). Although a few metabolic effects of metformin and the related biguanide phenformin have been investigated in established cancer cell lines, the global metabolic impact of biguanides during the process of neo...
Among ALDH isoforms, ALDH1L1 in the folate pathway showed highly increased expression in non-small-cell lung cancer cells (NSCLC). Based on the basic mechanism of ALDH converting aldehyde to carboxylic acid with by-product NADH, we suggested that ALDH1L1 may contribute to ATP production using NADH through oxidative phosphorylation. ALDH1L1 knockdown reduced ATP production by up to 60% concomita...
Mutation of p53 occasionally results in a gain of function, which promotes tumor growth. We asked whether destabilizing the gain-of-function protein would kill tumor cells. Downregulation of the gene reduced cell proliferation in p53-mutant cells, but not in p53-null cells, indicating that the former depended on the mutant protein for survival. Moreover, phenformin and 2-deoxyglucose suppressed...
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