the nitrite ® nitro isomerization in nitritopentaamine cobalt (iii) halides has been known. in this paper, the effect of the size of the counter ions (noncoordinated groups) on the rate of isomerization in nitritopentaamine cobalt (iii) halides, is reported. the rate of isomerization is decreased by increasing the size of the counter ions. this decrease is explained on the basis of steric inter...

Improved photo-labile protecting groups, with high sensitivity to two-photon excitation, are needed for the controlled release of drugs, as tools in neuroscience and physiology. Here we present a new modular approach to the design of caging groups based on photoinduced electron transfer from an electron-rich two-photon dye to an electron acceptor, followed by scission of an ester to release a c...

A copper-catalysed direct radical alkenylation of various benzyl bromides and α-carbonyl alkyl bromides has been developed. Compared with the recent radical alkenylations which mostly focused on secondary or tertiary alkyl halides, this transformation shows good reactivity to primary alkyl halides and tertiary, secondary alkyl halides were also tolerated. The key initiation step of this transfo...

A mild, efficient, and low-temperature palladium-catalyzed cyanation of (hetero)aryl halides and triflates is reported. Previous palladium-catalyzed cyanations of (hetero)aryl halides have required higher temperatures to achieve good catalytic activity. This current reaction allows the cyanation of a general scope of (hetero)aryl halides and triflates at 2-5 mol % catalyst loadings with tempera...

The title compound, C21H21NO, is a vinyl-ogous amide (enaminone) produced by reaction of 1-(2-phenyl-prop-2-en-1-yl)pyrrolidine-2-thione with phenacyl bromide. In the mol-ecule, the phenyl rings are twisted from the mean plane of the pyrrolidine ring by 11.2 (1) and 67.3 (1)°. In the crystal, weak C-H⋯O hydrogen bonds link the mol-ecules related by translation along the b axis into chains.

heterocyclic derivative contain triazole ring was synthesized and characterized the product their structures by infrared spectroscopy, 1H-NMR, 13C-NMR instrumental techniques. Compound (4) reacting of Schiff base (3) with an three moles alkyl halide (p-phenyl phenacyl bromide). Final played important role in photostabilizer polymer (PS), showed activity as a when exposed to UV light (300 hours).

4H-1,4-oxazines were designed as transthyretin (TTR) amyloid fibril inhibitors based on an analysis of the interactions between known small molecule inhibitors and TTR by molecular docking. A series of 2,4,6-triaryl-4H-1,4-oxazines was synthesized by the cyclization of N,N-bis(phenacyl)anilines with POCl3 in pyridine. Inhibition of TTR amyloid fibril was evaluated by a fibril formation assay. T...

ABSTRACT An efficient method for the synthesis of N,N-bis(phenacyl)anilines was developed via smooth condensation of anilines with α-bromoacetophenones in the presence of sodium carbonate as acid acceptor and polyethylene glycol 400 (PEG 400) as catalyst at room temperature under solvent-free conditions by using 350 W ultrasound irradiation. In addition to experimental simplicity, the main adva...

A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.