BACKGROUND Integrated phase II/III trial designs implement the phase II and phase III aspects of oncology studies into a single trial. Despite a body of literature discussing the merits of integrated phase II/III clinical trial designs within the past two decades, implementation of this design has been limited in oncology studies. PURPOSE We provide a brief discussion of the potential advanta...

Migrating motor complex (MMC) is well characterized by the appearance of gastrointestinal contractions in the interdigestive state. This review article discussed the mechanism of gastrointestinal MMC. Luminal administration of 5-hydroxytryptamine (5-HT) initiates duodenal phase II followed by gastrointestinal phase III with a concomitant increase of plasma motilin release in conscious dogs. Duo...

Migrating motor complex (MMC) is well characterized by the appearance of gastrointestinal (GI) contractions in the interdigestive state. The physiological importance of gastric MMC is a mechanical and chemical cleansing of the empty stomach in preparation for the next meal. MMC cycle is mediated via the interaction between motilin and 5-hydroxytryptamine (5-HT) by the positive feedback mechanis...

Purpose: Historical data from pilot, Phase II, and Phase III studies for patients with advanced-stage non-small cell lung cancer (NSCLC) were used to evaluate a statistical model developed to provide assistance in selecting regimens from pilot studies for subsequent use in larger Phase III randomized studies. Experimental Design: Information from 33 Phase III trials for patients with advanced-s...

The last phase of the life and work of Sigmund Freud 1919-1939, is described with love, devotion, and meticulous care, by his disciple, our own Ernest Jones. The progress and misfortune, the fame and suffering, the last years in Vienna and London, are described in the early chapters with historical reviews of his contributions in Part II, extracts and notes on the cancerous disease from which h...

Phase III development of a micro-hydroelectric power generating system is focused on enhancing the system designed by Phases I and II. The previous phases focused on the use of the Gorlov Helical Turbine (GHT) to derive power from a fresh water environment, specifically the Stevens River in Vermont. Phase III exclusively focused on deriving power from an ocean environment and the construction o...

Methane is the simplest organic molecule, and like many supposedly simple molecular materials it has a rich phase diagram. While crystal structures could be determined for two of the solid phases, that of the low temperature phase III remained unsolved. Using high-resolution neutron powder diffraction and a direct-space Monte Carlo simulated annealing approach, this fundamental structure has no...