S-CKD602 is a PEGylated liposomal formulation of CKD-602, a potent topoisomerase I inhibitor. The objective of this study was to characterize the bidirectional pharmacokinetic-pharmacodynamic (PK-PD) interaction between S-CKD602 and monocytes. Plasma concentrations of encapsulated CKD-602 and monocytes counts from 45 patients with solid tumors were collected following intravenous administration...

This work proposes a comparative analysis of sinusoidal and third harmonic injected reference signal modulation accompany with level-shifted PWM technique named as phase disposition (LSPD), opposition (LSPOD), alternate (LSAPOD) phase-shifted technique. Switching pulses from both have been fed into three eleven level cascaded H-bridge multilevel inverter (CHBMLI) on resistive-inductive load the...

Etrolizumab, a humanized monoclonal antibody, specifically binds to the β7 subunit of the heterodimeric integrins α4β7 and αEβ7. Pharmacokinetic (PK) and pharmacodynamic (PD) data were collected from an etrolizumab phase 1 trial in patients with moderate to severe ulcerative colitis (UC). We developed a mechanism-based model to simultaneously describe the kinetics of serum etrolizumab concentra...

The medium-frequency (MF) transformer in a phase-shift modulated dc solid state (SST) is prone to partial discharge (PD) that impacts the system reliability and lifetime. Tightly packed MF windings carrying pulsewidth modulation (PWM) voltages create favorable conditions for PD inception due proximity between adjacent winding conductors electric field enhancement because of spiral geometry. A p...

Analysis and practical implementation of the regular symmetric sampled three-phase PWM inverter waveform has been presented in this paper. It is digitally implemented on a Xilinx field programmable gate array FPGA, and the essential considerations involved in the feasibility of using a Xilinx XC4008E software-based to generate PWM has been discussed. All the necessary Xilinx hardware/software t...

In this paper, we present the performance of a hybrid alternative phase opposition disposition pulse width modulation technique for soft switched cascaded five level inverters. The proposed modulation scheme inherits the switching loss reduction along with reduced harmonic performance of cascaded multilevel inverter fed drive system. The inverter topology used here has recently suggested in the...

Multilevel cascaded and hybrid inverter systems conventionally use three level bipolar PWM for each individual inverter, with their carriers phase shifted to achieve maximum harmonic cancellation within each phase leg. This has been shown to give a harmonic performance equivalent to APOD modulation of a NPC multilevel inverter, when the switching frequencies are scaled to achieve the same numbe...

Multilevel voltage source inverter has been recognized as an important alternative to the normal two level voltage source inverter, especially in high power application. Using multilevel technique, the output voltage amplitude is increased, switching devices stress is reduced and the overall harmonics profile is improved. Three presentable topologies can b considered for multilevel inverter (ML...