نتایج جستجو برای: pharmacokinetic study

تعداد نتایج: 3982380  

2016
Erno van Schaick Marc A. Benninga Amy Levine Mats Magnusson Steven Troy

A recent phase 3 trial of prucalopride in children with functional constipation (SPD555-303 ClinicalTrials.gov Identifier: NCT01330381) reported negative efficacy results. Here, we developed a population pharmacokinetic (PK) model of prucalopride in children to assess prucalopride exposure in SPD555-303. An initial population PK model in children was developed based on sampled single-dose data ...

2014
Jeremy H. Toyn Lorin A. Thompson Kimberley A. Lentz Jere E. Meredith Catherine R. Burton Sethu Sankaranararyanan Valerie Guss Tracey Hall Lawrence G. Iben Carol M. Krause Rudy Krause Xu-Alan Lin Maria Pierdomenico Craig Polson Alan S. Robertson R. Rex Denton James E. Grace John Morrison Joseph Raybon Xiaoliang Zhuo Kimberly Snow Ramesh Padmanabha Michele Agler Kim Esposito David Harden Margaret Prack Sam Varma Victoria Wong Yingjie Zhu Tatyana Zvyaga Samuel Gerritz Lawrence R. Marcin Mendi A. Higgins Jianliang Shi Cong Wei Joseph L. Cantone Dieter M. Drexler John E. Macor Richard E. Olson Michael K. Ahlijanian Charles F. Albright

Alzheimer's disease is the most prevalent cause of dementia and is associated with accumulation of amyloid-β peptide (Aβ), particularly the 42-amino acid Aβ1-42, in the brain. Aβ1-42 levels can be decreased by γ-secretase modulators (GSM), which are small molecules that modulate γ-secretase, an enzyme essential for Aβ production. BMS-869780 is a potent GSM that decreased Aβ1-42 and Aβ1-40 and i...

Journal: :The Journal of antimicrobial chemotherapy 2010
Anne Sandberg Klaus Skovbo Jensen Pierre Baudoux Françoise Van Bambeke Paul M Tulkens Niels Frimodt-Møller

BACKGROUND AND AIMS Treatment of Staphylococcus aureus infections remains problematic (slow responses and frequent recurrences). Intracellular persistence of the S. aureus could explain those difficulties because of impaired intracellular efficacy of antibiotics. Our aim was to study linezolid for its intracellular activity. METHODS (i) Pharmacodynamic (PD) analysis of intracellular activity ...

Journal: :Antimicrobial agents and chemotherapy 2009
Allen C Cheng Emma S McBryde Vanaporn Wuthiekanun Wirongrong Chierakul Premjit Amornchai Nicholas P J Day Nicholas J White Sharon J Peacock

Melioidosis is an infectious disease with a propensity for relapse, despite prolonged antibiotic eradication therapy for 12 to 20 weeks. A pharmacokinetic (PK) simulation study was performed to determine the optimal dosing of cotrimoxazole (trimethoprim-sulfamethoxazole [TMP-SMX]) used in current eradication regimens in Thailand and Australia. Data for bioavailability, protein binding, and coef...

Journal: :The Journal of pharmacology and experimental therapeutics 2014
Yan Li Simon Zhou Matthew Hoffmann Gondi Kumar Maria Palmisano

Pomalidomide, a potent novel immunomodulatory agent, has been developed as a racemic mixture of its R- and S-isomers. Pharmacokinetic (PK) analyses were conducted to determine the PK disposition of the isomers from their PK profiles in humans and monkeys. Modeling and simulation were performed to describe the observed PK profiles and explore potential differences in isomer disposition and expos...

Journal: :Clinical pharmacokinetics 2015
Jules A A C Heuberger Zheng Guan Olubukayo-Opeyemi Oyetayo Linda Klumpers Paul D Morrison Tim L Beumer Joop M A van Gerven Adam F Cohen Jan Freijer

Δ(9)-Tetrahydrocannobinol (THC), the main psychoactive compound of Cannabis, is known to have a long terminal half-life. However, this characteristic is often ignored in pharmacokinetic (PK) studies of THC, which may affect the accuracy of predictions in different pharmacologic areas. For therapeutic use for example, it is important to accurately describe the terminal phase of THC to describe a...

Journal: :Antimicrobial agents and chemotherapy 2013
Mohamed A Kamal Scott A Van Wart Craig R Rayner Vishak Subramoney Daniel K Reynolds Catharine C Bulik Patrick F Smith Sujata M Bhavnani Paul G Ambrose Alan Forrest

Oseltamivir is a potent inhibitor of influenza virus neuraminidase enzymes essential for viral replication. This study aimed to investigate the impact of covariates on pharmacokinetic (PK) variability of oseltamivir and its active metabolite form, oseltamivir carboxylate (OC). Dosing history, plasma drug concentrations, and demographic information were pooled from 13 clinical trials providing d...

2005
Xavière Panhard France Mentré

Introduction: Pharmacokinetic (PK) interaction, or lack of interaction, of a drug B on a drug A, is usually tested by comparing the log AUC and the log Cmax of A given alone (or with placebo) versus A given with B. The standard method, recommended in guidelines, is the comparison of log AUC and log Cmax of A, using a Student test or a Schuirmann's two-one sided test (TOST) to test interaction o...

2016
HB Mistry M‐A Fabre J Young G Clack PA Dickinson

First-in-human (FIH) studies with AZD3514, a selective androgen receptor (AR) down-regulator, showed decreases of >30% in the prostate-specific antigen (PSA) in some patients. A modeling approach was adopted to understand these observations and define the optimum clinical use hypothesis for AZD3514 for clinical testing. Initial empirical modeling showed that only baseline PSA correlated signifi...

2010
Guido Filler Ajay Parkash Sharma Deborah M Levy Abeer Yasin

BACKGROUND : Therapy with mycophenolate mofetil (MMF) has become a valuable therapeutic option in children with autoimmune disease. MMF prescription in children with autoimmune diseases differs from that in transplant recipients in terms of different dosing regimen, and concomitant administration of other immunosuppressive medications. Recently, another formulation of the same active compound, ...

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