Dysfunction of parvalbumin (PV)-positive GABAergic interneurons (PVIs) within the prefrontal cortex (PFC) has been implicated in schizophrenia pathology. It is however unclear, how impaired signaling of these neurons may contribute to PFC dysfunction. To identify how PVIs contribute to PFC-dependent behaviors we inactivated PVIs in the PFC in mice using region- and cell-type-selective expressio...

How and where object and spatial information are perceptually integrated in the brain is a central question in visual cognition. Single-unit physiology, scalp EEG, and fMRI research suggests that the prefrontal cortex (PFC) is a critical locus for object-spatial integration. To test the causal participation of the PFC in an object-spatial integration network, we studied ten patients with unilat...

The prefrontal cortex (PFC) is among the most evolved brain regions, contributing to our highest order cognitive abilities. It regulates behavior, thought, and emotion using working memory. Many cognitive disorders involve impairments of the PFC. A century of discoveries at Yale Medical School has revealed the neurobiology of PFC cognitive functions, as well as the molecular needs of these circ...

Planar flow casting (PFC) is a method that can be used to make thin, long, and wide metallic alloy foils by extruding molten liquid through nozzle slot immediately quenching on moving roller. The rates are high enough amorphous glasses may formed have many desirable properties for variety of applications. This paper reviews how PFC processes were developed, examines the typical operability rang...

Regions of the prefrontal cortex (PFC) are typically activated in many different cognitive functions. In most studies, the focus has been on the role of specific PFC regions in specific cognitive domains, but more recently similarities in PFC activations across cognitive domains have been stressed. Such similarities may suggest that a region mediates a common function across a variety of cognit...

Working memory (WM) declines with advancing age. Brain imaging studies indicate that ventral prefrontal cortex (PFC) is active when information is retained in WM and that dorsal PFC is further activated for retention of large amounts of information. The authors examined the effect of aging on activation in specific PFC regions during WM performance. Six younger and 6 older adults performed a ta...

Findings from a number of studies have implicated the prefrontal cortex (PFC), especially the dorsolateral region, as a site of dysfunction in schizophrenia (Goldberg et al. 1989). For example, in contrast to controls, schizophrenics fail to activate the dorsolateral PFC while engaged in the Wisconsin Card Sort Task (Weinberger et al. 1986), and they exhibit an inability to learn how to perform...

Immunization of rabbits or mice with a single, chemically defined hapten elicits populations of plaque-forming cells (PFC) detectable not only on sheep erythrocytes (SRBC) bearing the immunizing hapten, but also on SRBC bearing structural analogues of the immunizing hapten. Most of these analogue-reactive PFC preferentially lyse analogue-conjugated SRBC and cannot be detected on erythrocytes be...

Strong evidence implicates prefrontal cortex (PFC) as a major source of functional impairment in severe mental illness such as schizophrenia. Numerous schizophrenia studies report deficits in PFC structure, activation, and functional connectivity in patients with chronic illness, suggesting that deficient PFC functional connectivity occurs in this disorder. However, the PFC functional connectiv...

In this study, we introduce the importance of elevated membrane potentials (MPs) in prefrontal cortex (PFC) compared to that posterior parietal (PPC), based on new observations different MP levels these areas. Through experimental data and spiking neural network modeling, investigated a possible mechanism potential PFC how physiological differences affect dynamics cognitive functions PPC PFC. O...